Gene Review:
Stard6 - StAR-related lipid transfer (START) domain...
Rattus norvegicus
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High impact information on Stard6
- Western blot analysis with Stard6 antibody revealed a 28-kDa Stard6 protein only in testis [1].
- Expression of the putative sterol binding protein Stard6 gene is male germ cell specific [1].
- Stard6 cDNA consists of 1146 base pairs of nucleotides and has the longest open reading frame, of 227 amino acids [1].
- From the subtracted cDNA library of rat testis prepared using the representational difference analysis (RDA) method, we isolated the cDNA clone of steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) protein 6 (Stard6) [1].
- Moreover, in situ hybridization showed Stard6 mRNA expression to be germ cell-specific and expressed only during the maturation stages of round and elongated spermatids of adult rat testis [1].
Anatomical context of Stard6
- Taken together, these results suggest that Stard6, a member of the START protein family, may play a role during germ cell maturation in adult rat testis [1].
Analytical, diagnostic and therapeutic context of Stard6
- Northern blot analysis revealed Stard6 mRNA to be testis-specific [1].
- Immunohistochemistry further confirmed localization of Stard6 protein expressed in mature germ cells, in concert with the in situ hybridization result [1].
References
- Expression of the putative sterol binding protein Stard6 gene is male germ cell specific. Gomes, C., Oh, S.D., Kim, J.W., Chun, S.Y., Lee, K., Kwon, H.B., Soh, J. Biol. Reprod. (2005) [Pubmed]
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