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Gene Review

Klk1c12  -  kallikrein 1-related peptidase C12

Rattus norvegicus

Synonyms: Glandular kallikrein-12, submandibular/renal, Klk-12, Klk1, Klk12, RSKG-3, ...
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Disease relevance of Klk12

  • Rats were infused with tissue kallikrein protein 5 days before (pretreated group) or after (treated group) ischemia [1].
  • These results indicate that tissue kallikrein, through the kinin B2 receptor, reverses salt-induced inflammation, renal fibrosis, and glomerular hypertrophy via suppression of oxidative stress [2].

High impact information on Klk12


  1. Early activation of bradykinin B2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury. Chiang, W.C., Chien, C.T., Lin, W.W., Lin, S.L., Chen, Y.M., Lai, C.F., Wu, K.D., Chao, J., Tsai, T.J. Free Radic. Biol. Med. (2006) [Pubmed]
  2. Reversal of renal fibrosis, inflammation, and glomerular hypertrophy by kallikrein gene delivery. Bledsoe, G., Shen, B., Yao, Y., Zhang, J.J., Chao, L., Chao, J. Hum. Gene Ther. (2006) [Pubmed]
  3. Molecular cloning and characterization of two rat renal kallikrein genes. Chen, Y.P., Chao, J., Chao, L. Biochemistry (1988) [Pubmed]
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