The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Klk1c3  -  kallikrein 1-related peptidase C3

Rattus norvegicus

Synonyms: KLK3, Klk1c10l2, RSGK-50, RSKG-50, rGK-3
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LOC292872

  • CONCLUSIONS: These findings indicated that kallikrein gene delivery attenuates hypertension and protects against renal injury and cardiac remodeling in the rat remnant kidney model of chronic renal failure [1].
  • Two weeks after gene delivery, the effect of kallikrein on renal fibrosis was examined by biochemical and histologic analysis [2].
  • Myocardial hypertrophy and fibrosis were also attenuated in rats receiving kallikrein gene delivery [1].
  • A maximal blood pressure reduction of 37 mm Hg was observed within one week in rats receiving kallikrein gene delivery as compared with control rats receiving adenovirus containing the luciferase gene (159 +/- 5 vs. 196 +/- 6 mm Hg, N = 15, P < 0.001), and a significant blood pressure difference continued for five weeks postgene delivery [1].
  • In Western blot analyses, a specific monoclonal antibody to tissue kallikrein (V4D11) identifies GH3-secreted kallikrein as a approximately 39,000 Da protein, slightly larger than approximately 38,000 Da kallikreins of submandibular gland, mouse anterior pituitary cells (AtT 20) or rodent neuroblastoma X glioma hybrid cells (NG108) [3].

Psychiatry related information on LOC292872

  • Water deprivation for 24 h resulted, also in both strains, in a similar reduction in urinary kallikrein excretion [4].

High impact information on LOC292872

  • These pulmonary lesions were prevented when the infected animals were treated with H-D-Pro-Phe-Arg-chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, suggesting that inhibition of contact system activation could be used therapeutically in severe infectious disease [5].
  • Hoe 140, a bradykinin B2-receptor antagonist, had no effect on the hypotensive effect of kallistatin yet it abolished the blood pressure-lowering effect of kinin and kallikrein [6].
  • Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its activity [6].
  • A maximal effect of blood pressure reduction of 46 mmHg in rats was observed 2-3 wk after injection with kallikrein DNA as compared to rats with vector DNA (n = 6, P < 0.05) [7].
  • These results show that direct gene delivery of human tissue kallikrein causes a sustained reduction in systolic blood pressure in genetically hypertensive rats and indicate that the feasibility of kallikrein gene therapy for treating human hypertension should be studied [7].

Chemical compound and disease context of LOC292872


Biological context of LOC292872


Anatomical context of LOC292872


Associations of LOC292872 with chemical compounds

  • The results indicate that T-kininogenase belongs to the group of structurally similar yet distinct kallikrein-like serine proteases [12].
  • After gene delivery, human kallikrein mRNA was identified at the injured vessel and a 3-fold increase occurred in kininogenase activity. cAMP and cGMP levels in balloon-injured aorta increased significantly at 4, 7, and 14 days after kallikrein gene delivery, but icatibant abolished the increase [13].
  • In dot blot analysis, kallikrein mRNA levels were increased 5-fold by 17 beta-estradiol in the whole pituitary of castrated male rats [18].
  • Kallikrein gene delivery significantly decreased total urinary protein and albumin excretion and increased levels of urinary kinin, nitrite/nitrate, and cGMP levels [1].
  • Tissue kallikrein synthesis and its modification by testosterone or low dietary sodium [17].

Regulatory relationships of LOC292872


Other interactions of LOC292872


Analytical, diagnostic and therapeutic context of LOC292872


  1. Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure. Wolf, W.C., Yoshida, H., Agata, J., Chao, L., Chao, J. Kidney Int. (2000) [Pubmed]
  2. Tissue kallikrein attenuates salt-induced renal fibrosis by inhibition of oxidative stress. Zhang, J.J., Bledsoe, G., Kato, K., Chao, L., Chao, J. Kidney Int. (2004) [Pubmed]
  3. Identification of latent tissue kallikrein, prolactin and growth hormone secretion in GH3 pituitary cells using modified radioimmunoassays. Chao, J., Chao, L. Mol. Cell. Endocrinol. (1988) [Pubmed]
  4. The renal kallikrein-kinin system in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Missing relationship between antidiuretic hormone and the renal kallikrein-kinin system. Bönner, G., Rascher, W., Speck, G., Marin-Grez, M., Gross, F. Acta Endocrinol. (1981) [Pubmed]
  5. Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system. Persson, K., Mörgelin, M., Lindbom, L., Alm, P., Björck, L., Herwald, H. J. Exp. Med. (2000) [Pubmed]
  6. Kallistatin is a potent new vasodilator. Chao, J., Stallone, J.N., Liang, Y.M., Chen, L.M., Wang, D.Z., Chao, L. J. Clin. Invest. (1997) [Pubmed]
  7. Direct gene delivery of human tissue kallikrein reduces blood pressure in spontaneously hypertensive rats. Wang, C., Chao, L., Chao, J. J. Clin. Invest. (1995) [Pubmed]
  8. Kallikrein gene expression in estrogen-induced pituitary tumors. Fuller, P.J., Matheson, B.A., MacDonald, R.J., Verity, K., Clements, J.A. Mol. Cell. Endocrinol. (1988) [Pubmed]
  9. A synthetic tissue kallikrein inhibitor suppresses cancer cell invasiveness. Wolf, W.C., Evans, D.M., Chao, L., Chao, J. Am. J. Pathol. (2001) [Pubmed]
  10. Kallikrein gene delivery improves serum glucose and lipid profiles and cardiac function in streptozotocin-induced diabetic rats. Montanari, D., Yin, H., Dobrzynski, E., Agata, J., Yoshida, H., Chao, J., Chao, L. Diabetes (2005) [Pubmed]
  11. Kallikrein gene transfer reduces renal fibrosis, hypertrophy, and proliferation in DOCA-salt hypertensive rats. Xia, C.F., Bledsoe, G., Chao, L., Chao, J. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  12. Purification and characterization of a kallikrein-like T-kininogenase. Xiong, W., Chen, L.M., Chao, J. J. Biol. Chem. (1990) [Pubmed]
  13. Kallikrein gene delivery inhibits vascular smooth muscle cell growth and neointima formation in the rat artery after balloon angioplasty. Murakami, H., Yayama, K., Miao, R.Q., Wang, C., Chao, L., Chao, J. Hypertension (1999) [Pubmed]
  14. Tissue-specific expression of kallikrein-related genes in the rat. Ashley, P.L., MacDonald, R.J. Biochemistry (1985) [Pubmed]
  15. Characterization of genes encoding rat tonin and a kallikrein-like serine protease. Shai, S.Y., Woodley-Miller, C., Chao, J., Chao, L. Biochemistry (1989) [Pubmed]
  16. Tissue kallikrein and tonin levels in submandibular glands of STZ-induced diabetic rats and the effects of insulin. Chan, K.M., Chao, J., Proctor, G.B., Garrett, J.R., Shori, D.K., Anderson, L.C. Diabetes (1993) [Pubmed]
  17. Tissue kallikrein synthesis and its modification by testosterone or low dietary sodium. Miller, D.H., Chao, J., Margolius, H.S. Biochem. J. (1984) [Pubmed]
  18. Tissue kallikrein in rat brain and pituitary: regional distribution and estrogen induction in the anterior pituitary. Chao, J., Chao, L., Swain, C.C., Tsai, J., Margolius, H.S. Endocrinology (1987) [Pubmed]
  19. Kallikrein-gene expression in the rat gastrointestinal tract. Fuller, P.J., Verity, K., Matheson, B.A., Clements, J.A. Biochem. J. (1989) [Pubmed]
  20. Intestinal absorption of glandular kallikrein in the rat. Overlack, A., Scicli, A.G., Carretero, O.A. Am. J. Physiol. (1983) [Pubmed]
  21. Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme. Swift, G.H., Dagorn, J.C., Ashley, P.L., Cummings, S.W., MacDonald, R.J. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  22. Submandibular enzymatic vasoconstrictor messenger RNA in rat kidney. Saed, G.M., Beierwaltes, W.H., Carretero, O.A., Scicli, A.G. Hypertension (1992) [Pubmed]
  23. Identification, purification, and localization of tissue kallikrein in rat heart. Xiong, W., Chen, L.M., Woodley-Miller, C., Simson, J.A., Chao, J. Biochem. J. (1990) [Pubmed]
  24. Purification and characterization of a serine protease (esterase B) from rat submandibular glands. Khullar, M., Scicli, G., Carretero, O.A., Scicli, A.G. Biochemistry (1986) [Pubmed]
  25. Specific identification of tissue kallikrein in exocrine tissues and in cell-free translation products with monoclonal antibodies. Woodley, C.M., Chao, J., Margolius, H.S., Chao, L. Biochem. J. (1985) [Pubmed]
WikiGenes - Universities