High impact information on Klk1c10

• Its T-kininogenase but not N-tosyl-L-arginine methyl ester esterase activity can be enhanced 10-fold in the presence of dithiothreitol [1].
• A T-kininogenase has been purified to homogeneity from rat submandibular gland extracts by DEAE-Sepharose chromatography and preparative gel electrophoresis [1].
• The results indicate that T-kininogenase belongs to the group of structurally similar yet distinct kallikrein-like serine proteases [1].
• Substrate specificities of tissue kallikrein and T-kininogenase: their possible role in kininogen processing [2].
• Antigen gamma released a kinin which was identified as T-kinin by reverse-phase h.p.l.c. The T-kininogenase activity of antigen gamma had a Km of 29 +/- 4 microM and a kcat/Km of 140 M-1.s-1, and was comparable with its high and low molecular mass-kininogenase activity (7.4 and 10 micrograms of kinin/h per mg respectively) [3].

Biological context of Klk1c10

• Sex dimorphism and inflammatory regulation of T-kininogen and T-kininogenase [4].

Anatomical context of Klk1c10

• Isolation and properties of a T-kininogenase from bovine erythrocyte membranes [5].
• These results suggest that there are two kinin-generating systems in rat myocardium comprising T-kininogen/T-kininogenase and L-kininogen/true kallikrein respectively, and that the former may be relatively important in inflammatory diseases or conditions in which cAMP levels increase in cardiomyocytes [6].

Associations of Klk1c10 with chemical compounds

• All of these mRNAs for the kallikrein-kinin system were also detected in cultured cardiomyocytes derived from neonatal rat ventricles; dibutyryl cyclic AMP, LPS or inflammatory cytokines such as interleukin-1 and tumor necrosis factor, up-regulated mRNA expression of T-kininogen, T-kininogenase, or B1 receptor in these cells in vitro [6].

Other interactions of Klk1c10

• 1. rK10, a weak T-kininogenase isolated from the rat submandibular gland, is a protein belonging to the rat kallikrein family [7].

Analytical, diagnostic and therapeutic context of Klk1c10

• Molecular cloning and characterization of rKlk10, a cDNA encoding T-kininogenase from rat submandibular gland and kidney [8].
• Simple, sensitive and specific radioimmunoassays were developed for measuring both T-kininogen and T-kininogenase [4].

References