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Gene Review

Klk1c10  -  kallikrein 1-related peptidase C10

Rattus norvegicus

Synonyms: Klk10, rGK-10
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High impact information on Klk1c10


Biological context of Klk1c10


Anatomical context of Klk1c10


Associations of Klk1c10 with chemical compounds

  • All of these mRNAs for the kallikrein-kinin system were also detected in cultured cardiomyocytes derived from neonatal rat ventricles; dibutyryl cyclic AMP, LPS or inflammatory cytokines such as interleukin-1 and tumor necrosis factor, up-regulated mRNA expression of T-kininogen, T-kininogenase, or B1 receptor in these cells in vitro [6].

Other interactions of Klk1c10


Analytical, diagnostic and therapeutic context of Klk1c10


  1. Purification and characterization of a kallikrein-like T-kininogenase. Xiong, W., Chen, L.M., Chao, J. J. Biol. Chem. (1990) [Pubmed]
  2. Substrate specificities of tissue kallikrein and T-kininogenase: their possible role in kininogen processing. Chagas, J.R., Hirata, I.Y., Juliano, M.A., Xiong, W., Wang, C., Chao, J., Juliano, L., Prado, E.S. Biochemistry (1992) [Pubmed]
  3. T-kininogenase activity of the rat submandibular gland is predominantly due to the kallikrein-like serine protease antigen gamma. Berg, T., Wassdal, I., Mindroiu, T., Sletten, K., Scicli, G., Carretero, O.A., Scicli, A.G. Biochem. J. (1991) [Pubmed]
  4. Sex dimorphism and inflammatory regulation of T-kininogen and T-kininogenase. Chao, S., Chao, L., Chao, J. Biochim. Biophys. Acta (1989) [Pubmed]
  5. Isolation and properties of a T-kininogenase from bovine erythrocyte membranes. Ferreira, L.A., Bergamasco, M., Henriques, O.B. J. Protein Chem. (1994) [Pubmed]
  6. Expression of kininogen, kallikrein and kinin receptor genes by rat cardiomyocytes. Yayama, K., Nagaoka, M., Takano, M., Okamoto, H. Biochim. Biophys. Acta (2000) [Pubmed]
  7. Kallikrein rK10-induced kinin-independent, direct activation of NO-formation and relaxation of rat isolated aortic rings. Wassdal, I., Hull, R., Gerskowitch, V.P., Berg, T. Br. J. Pharmacol. (1995) [Pubmed]
  8. Molecular cloning and characterization of rKlk10, a cDNA encoding T-kininogenase from rat submandibular gland and kidney. Ma, J.X., Chao, J., Chao, L. Biochemistry (1992) [Pubmed]
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