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Csrp2  -  cysteine and glycine-rich protein 2

Rattus norvegicus

Synonyms: CRP2, Cysteine and glycine-rich protein 2, Cysteine-rich protein 2, SmLIM, Smlim, ...
 
 
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High impact information on Csrp2

  • In contrast to the actin-binding proteins SM22alpha and alpha-actinin, GFP-CRP2 did not translocate into the podosomes induced by this treatment, but remained preferentially bound to the stress fibres, suggesting an actin filament-stabilising role for CRP2 [1].
  • Using a green fluorescent protein (GFP)-tagged construct of CRP2 we analysed its localisation and dynamics in A7r5 rat smooth muscle cells [1].
  • CRP2 was associated with the actin cytoskeleton and decorated actin stress fibres in a continuous fashion, unlike the periodic labelling pattern observed for alpha-actinin and zyxin, which also accumulate in focal adhesions [1].
  • Finally, four genes, caveolin-1, two LIM proteins (enigma and SmLIM) and Id3a, were identified [2].

References

  1. CRP2 is an autonomous actin-binding protein. Grubinger, M., Gimona, M. FEBS Lett. (2004) [Pubmed]
  2. Caveolin-1, Id3a and two LIM protein genes are upregulated by estrogen in vascular smooth muscle cells. Watanabe, T., Akishita, M., Nakaoka, T., He, H., Miyahara, Y., Yamashita, N., Wada, Y., Aburatani, H., Yoshizumi, M., Kozaki, K., Ouchi, Y. Life Sci. (2004) [Pubmed]
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