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Gene Review

Actn1  -  actinin, alpha 1

Rattus norvegicus

Synonyms: Alpha-actinin cytoskeletal isoform, Alpha-actinin-1, F-actin cross-linking protein, Non-muscle alpha-actinin-1
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Disease relevance of Actn1


High impact information on Actn1


Chemical compound and disease context of Actn1


Biological context of Actn1


Anatomical context of Actn1

  • In transfected COS-7 cells, complexes of Pdlim2 and alpha-actinin-1 were preferentially located along the basal aspect [16].
  • By immunoelectron microscopy the podocyte foot processes of the rat and human kidney have been shown to contain three major proteins of the contractile apparatus in muscle, i.e., actin, myosin, and the Z-line protein, alpha-actinin [17].
  • Assuming that actin, myosin, and alpha-actinin are arranged in a way that would allow the foot processes to generate contractile force this filament system might help the glomerular capillaries to resist the high intraluminal hydrostatic pressure as well as to actively modify the surface area for filtration [17].
  • Becaused such unusual structures may provide an understanding of cell-surface assemblies important in determining cell morphology, we have developed a procedure for isolating the branched microvilli and have shown that they contain significant quantities of alpha-actinin [1].
  • Talin and alpha-actinin were degraded in a time-dependent manner, although no apparent changes of actin filament were observed [6].

Associations of Actn1 with chemical compounds


Physical interactions of Actn1


Co-localisations of Actn1


Other interactions of Actn1


Analytical, diagnostic and therapeutic context of Actn1


  1. alpha-Actinin-containing branched microvilli isolated from an ascites adenocarcinoma. Carraway, K.L., Huggins, J.W., Cerra, R.F., Yeltman, D.R., Carraway, C.A. Nature (1980) [Pubmed]
  2. Thymic B lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, alpha actinin, or actin. Williams, C.L., Lennon, V.A. J. Exp. Med. (1986) [Pubmed]
  3. Alpha-actinin-containing aggregates in transformed cells are highly dynamic structures. Stickel, S.K., Wang, Y.L. J. Cell Biol. (1987) [Pubmed]
  4. Breakdown and release of myofilament proteins during ischemia and ischemia/reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation. Van Eyk, J.E., Powers, F., Law, W., Larue, C., Hodges, R.S., Solaro, R.J. Circ. Res. (1998) [Pubmed]
  5. Cytoskeletal lesions in anoxic myocardial injury. A conventional and high-voltage electron-microscopic and immunofluorescence study. Ganote, C.E., Vander Heide, R.S. Am. J. Pathol. (1987) [Pubmed]
  6. Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury. Miyoshi, H., Umeshita, K., Sakon, M., Imajoh-Ohmi, S., Fujitani, K., Gotoh, M., Oiki, E., Kambayashi, J., Monden, M. Gastroenterology (1996) [Pubmed]
  7. Restructuring of focal adhesion plaques by PI 3-kinase. Regulation by PtdIns (3,4,5)-p(3) binding to alpha-actinin. Greenwood, J.A., Theibert, A.B., Prestwich, G.D., Murphy-Ullrich, J.E. J. Cell Biol. (2000) [Pubmed]
  8. The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism. Young, P., Gautel, M. EMBO J. (2000) [Pubmed]
  9. Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts. Kawano, H., Cody, R.J., Graf, K., Goetze, S., Kawano, Y., Schnee, J., Law, R.E., Hsueh, W.A. Hypertension (2000) [Pubmed]
  10. A multi-mutant herpes simplex virus vector has minimal cytotoxic effects on the distribution of filamentous actin, alpha-actinin 2 and a glutamate receptor in differentiated PC12 cells. Holmes, K.D., Cassam, A.K., Chan, B., Peters, A.A., Weaver, L.C., Dekaban, G.A. J. Neurovirol. (2000) [Pubmed]
  11. Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid. Siddiqui, R.A., Shaikh, S.R., Kovacs, R., Stillwell, W., Zaloga, G. J. Cell. Biochem. (2004) [Pubmed]
  12. Key molecular events in puromycin aminonucleoside nephrosis rats. Guan, N., Ding, J., Deng, J., Zhang, J., Yang, J. Pathol. Int. (2004) [Pubmed]
  13. Brain-specific splicing of alpha-actinin 1 (ACTN1) mRNA. Kremerskothen, J., Teber, I., Wendholt, D., Liedtke, T., Böckers, T.M., Barnekow, A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  14. Annexin VI-binding proteins in brain. Interaction of annexin VI with a membrane skeletal protein, calspectin (brain spectrin or fodrin). Watanabe, T., Inui, M., Chen, B.Y., Iga, M., Sobue, K. J. Biol. Chem. (1994) [Pubmed]
  15. Identification of the 52 kDa cytoskeletal-like protein of cytochalasin D-stimulated normal rat kidney (NRK/CD) cells as substrate-associated glycoprotein p52 [plasminogen-activator inhibitor type-1 (PAI-1)]. Expression of p52 (PAI-1) in NRK/CD cells is regulated at the level of mRNA abundance. Higgins, P.J., Ryan, M.P. Biochem. J. (1992) [Pubmed]
  16. Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Torrado, M., Senatorov, V.V., Trivedi, R., Fariss, R.N., Tomarev, S.I. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  17. Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man. Drenckhahn, D., Franke, R.P. Lab. Invest. (1988) [Pubmed]
  18. Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Lehtonen, S., Ryan, J.J., Kudlicka, K., Iino, N., Zhou, H., Farquhar, M.G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  19. Phospholipase D activity is required for actin stress fiber formation in fibroblasts. Kam, Y., Exton, J.H. Mol. Cell. Biol. (2001) [Pubmed]
  20. In vitro regulation of granulosa cell differentiation. Involvement of cytoskeletal protein expression. Ben-Ze'ev, A., Amsterdam, A. J. Biol. Chem. (1987) [Pubmed]
  21. Drebrin, a development-associated brain protein from rat embryo, causes the dissociation of tropomyosin from actin filaments. Ishikawa, R., Hayashi, K., Shirao, T., Xue, Y., Takagi, T., Sasaki, Y., Kohama, K. J. Biol. Chem. (1994) [Pubmed]
  22. In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function. Van de Water, B., Jaspers, J.J., Maasdam, D.H., Mulder, G.J., Nagelkerke, J.F. Am. J. Physiol. (1994) [Pubmed]
  23. Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats. Yi, X.P., Gerdes, A.M., Li, F. Hypertension (2002) [Pubmed]
  24. alpha-actinin-2 in rat striatum: localization and interaction with NMDA glutamate receptor subunits. Dunah, A.W., Wyszynski, M., Martin, D.M., Sheng, M., Standaert, D.G. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  25. The neural cell adhesion molecule is associated with major components of the cytoskeleton. Büttner, B., Kannicht, C., Reutter, W., Horstkorte, R. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  26. Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins. Wu, X., Davis, G.E., Meininger, G.A., Wilson, E., Davis, M.J. J. Biol. Chem. (2001) [Pubmed]
  27. Regulation of single NMDA receptor channel activity by alpha-actinin and calmodulin in rat hippocampal granule cells. Rycroft, B.K., Gibb, A.J. J. Physiol. (Lond.) (2004) [Pubmed]
  28. Effects of profilin and profilactin on actin structure and function in living cells. Cao, L.G., Babcock, G.G., Rubenstein, P.A., Wang, Y.L. J. Cell Biol. (1992) [Pubmed]
  29. Can grafted cardiomyocytes colonize peri-infarct myocardial areas? Scorsin, M., Marotte, F., Sabri, A., Le Dref, O., Demirag, M., Samuel, J.L., Rappaport, L., Menasché, P. Circulation (1996) [Pubmed]
  30. Altered distributions of the cytoskeletal proteins vinculin and alpha-actinin in cultured fibroblasts transformed by Rous sarcoma virus. David-Pfeuty, T., Singer, S.J. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  31. Ultrastructural organization of contractile proteins in rat glomerular mesangial cells. Drenckhahn, D., Schnittler, H., Nobiling, R., Kriz, W. Am. J. Pathol. (1990) [Pubmed]
  32. Cell-to-substratum contacts in living cells: a direct correlation between interference-reflexion and indirect-immunofluorescence microscopy using antibodies against actin and alpha-actinin. Wehland, J., Osborn, M., Weber, K. J. Cell. Sci. (1979) [Pubmed]
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