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Gene Review

Zyx  -  zyxin

Rattus norvegicus

 
 
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Disease relevance of Zyx

  • When fused to the mitochondrial targeting sequence from the Listeria protein ActA, GFP-CRP2 was almost completely localised to mitochondria, but no significant recruitment of either alpha-actinin or zyxin could be observed [1].
  • Mapping of Zyx coding for zyxin in the rat and its exclusion as a candidate gene for lymphopenia [2].
 

High impact information on Zyx

  • Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus [3].
  • Furthermore, we demonstrate that native zyxin shuttles between the nucleus and sites of cell adhesion in fibroblasts and is thus an excellent candidate for relaying information between these two compartments [3].
  • Here we show that zyxin exhibits a functional nuclear export signal that is required to keep zyxin concentrated in the cytoplasm and is sufficient to direct nuclear proteins to the cytosol [3].
  • Concentration of Arp2/3 coincides with podosome formation and precedes the engagement of SM22 and alpha-actinin, while the focal adhesion components zyxin and vinculin redistribute only at later stages of podosome development [4].
  • Co-localizations with the adhesion molecules vinculin and zyxin at the proximal part of growth cones were observed [5].
 

Biological context of Zyx

 

Anatomical context of Zyx

 

Other interactions of Zyx

  • Thus, stretch-induced endothelin B receptor expression, for example, was attenuated, whereas that of tenascin-C was augmented after zyxin suppression [6].

References

  1. CRP2 is an autonomous actin-binding protein. Grubinger, M., Gimona, M. FEBS Lett. (2004) [Pubmed]
  2. Mapping of Zyx coding for zyxin in the rat and its exclusion as a candidate gene for lymphopenia. Hornum, L., Markholst, H. Cytogenet. Cell Genet. (2000) [Pubmed]
  3. Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. Nix, D.A., Beckerle, M.C. J. Cell Biol. (1997) [Pubmed]
  4. Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains. Kaverina, I., Stradal, T.E., Gimona, M. J. Cell. Sci. (2003) [Pubmed]
  5. Synaptotagmin I and IV define distinct populations of neuronal transport vesicles. Berton, F., Cornet, V., Iborra, C., Garrido, J., Dargent, B., Fukuda, M., Seagar, M., Marquèze, B. Eur. J. Neurosci. (2000) [Pubmed]
  6. Focal adhesion protein zyxin is a mechanosensitive modulator of gene expression in vascular smooth muscle cells. Cattaruzza, M., Lattrich, C., Hecker, M. Hypertension (2004) [Pubmed]
  7. Expression of VASP and zyxin in cochlear pillar cells: indication for actin-based dynamics? Schick, B., Praetorius, M., Eigenthaler, M., Mack, A., Plinkert, P., Walter, U., Dazert, S., Knipper, M. Cell Tissue Res. (2003) [Pubmed]
 
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