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Gene Review: 

Tars  -  threonyl-tRNA synthetase

Rattus norvegicus

Synonyms: ThrRS, Threonine--tRNA ligase, cytoplasmic, Threonyl-tRNA synthetase
 
 
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Disease relevance of Tars

  • Nucleotide and deduced amino acid sequence of human threonyl-tRNA synthetase reveals extensive homology to the Escherichia coli and yeast enzymes [1].
  • Myositis autoantibody reactivity and catalytic function of threonyl-tRNA synthetase [2].
  • Spontaneously occurring autoantibody to threonyl-tRNA synthetase found in the serum of patients with polymyositis and experimentally induced antibody against highly purified rabbit reticulocyte threonyl-tRNA synthetase were used to analyze the epitopes of threonyl-tRNA synthetase [2].
 

High impact information on Tars

  • In addition, the PL-7 autoantibody specifically inhibited threonyl-tRNA synthetase activity whereas the experimentally induced antibody had no effect on aminoacylation [2].
  • The nucleotide sequence of a cDNA coding human threonyl-tRNA synthetase has been determined [1].
  • Since it selectively inhibits threonyl-tRNA synthetase, we examined the effect of threonine on its anti-angiogenic activity [3].
  • Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells [3].
 

Associations of Tars with chemical compounds

References

  1. Nucleotide and deduced amino acid sequence of human threonyl-tRNA synthetase reveals extensive homology to the Escherichia coli and yeast enzymes. Cruzen, M.E., Arfin, S.M. J. Biol. Chem. (1991) [Pubmed]
  2. Myositis autoantibody reactivity and catalytic function of threonyl-tRNA synthetase. Dang, C.V., Tan, E.M., Traugh, J.A. FASEB J. (1988) [Pubmed]
  3. Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. Kawamura, T., Liu, D., Towle, M.J., Kageyama, R., Tsukahara, N., Wakabayashi, T., Littlefield, B.A. J. Antibiot. (2003) [Pubmed]
  4. Spermine stimulates the threonyl-tRNA formation in rat liver. Aoyama, H. Chem. Biol. Interact. (1990) [Pubmed]
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