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Gene Review

Arntl  -  aryl hydrocarbon receptor nuclear...

Rattus norvegicus

Synonyms: Aryl hydrocarbon receptor nuclear translocator-like protein 1, Bmal1, Brain and muscle ARNT-like 1, Tic
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High impact information on Arntl

  • The results presented here indicate a robust circadian expression of clock genes (e.g. Per1 and Bmal1) and the probable existence of a peripheral oscillator in the pancreas [1].
  • Per1, Per3, Bmal1 and AVP expression patterns were, however, significantly but differentially affected, during the second subjective night after the melatonin injection [2].
  • Expression of Cry1 was affected only in 20-day-old pups, whereas expression of Bmal1 was not yet affected even in 20-day-old rats [3].
  • The rhythmic expression of clock and clock-controlled genes in the rat oviduct was investigated by real time RT-PCR. per1, per2, Clock, Bmal1, cry1 and cry2 were all expressed in the oviduct [4].
  • Interspecies backcross and FISH mapping have been used to localize the Tic gene to mouse Chromosome (Chr) 7 F2-F3, given the locus name Arntl [5].

Other interactions of Arntl

  • To determine whether melatonin feedback control on SCN activity implicates transcriptional regulation of the clock genes, we monitored the expression pattern of Per 1, 2, 3, Bmal1, Cry1 and AVP mRNAs after a single melatonin injection at the end of the subjective day [2].

Analytical, diagnostic and therapeutic context of Arntl


  1. Indication of circadian oscillations in the rat pancreas. Mühlbauer, E., Wolgast, S., Finckh, U., Peschke, D., Peschke, E. FEBS Lett. (2004) [Pubmed]
  2. Contrary to other non-photic cues, acute melatonin injection does not induce immediate changes of clock gene mRNA expression in the rat suprachiasmatic nuclei. Poirel, V.J., Boggio, V., Dardente, H., Pevet, P., Masson-Pevet, M., Gauer, F. Neuroscience (2003) [Pubmed]
  3. Ontogenesis of photoperiodic entrainment of the molecular core clockwork in the rat suprachiasmatic nucleus. Kováciková, Z., Sládek, M., Laurinová, K., Bendová, Z., Illnerová, H., Sumová, A. Brain Res. (2005) [Pubmed]
  4. Rhythmic expression of clock and clock-controlled genes in the rat oviduct. Kennaway, D.J., Varcoe, T.J., Mau, V.J. Mol. Hum. Reprod. (2003) [Pubmed]
  5. Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family. Wolting, C.D., McGlade, C.J. Mamm. Genome (1998) [Pubmed]
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