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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Table of contents

About

Terms

 

Gene Review: 

Cry1  -  cryptochrome circadian clock 1

Rattus norvegicus

Synonyms: Cryptochrome-1
 
 
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High impact information on Cry1

  • Expression of Cry1 was affected only in 20-day-old pups, whereas expression of Bmal1 was not yet affected even in 20-day-old rats [1].
  • The expression of Per3 and Cry1 displays a daily rhythm not regulated by norepinephrine, suggesting the involvement of another day/night regulated transmitter(s) [2].
  • Amplitude of Per1, Cry1, and Bmal1 mRNA rhythms was larger under the short than under the long photoperiod [3].
  • Melatonin induces Cry1 expression in the pars tuberalis of the rat [4].
  • The peak of Cry1 mRNA expression occurs during the night concomitantly with rising blood plasma melatonin concentrations [4].
 

Biological context of Cry1

 

Anatomical context of Cry1

 

Associations of Cry1 with chemical compounds

 

Other interactions of Cry1

  • But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm [5].
 

Analytical, diagnostic and therapeutic context of Cry1

References

  1. Ontogenesis of photoperiodic entrainment of the molecular core clockwork in the rat suprachiasmatic nucleus. Kováciková, Z., Sládek, M., Laurinová, K., Bendová, Z., Illnerová, H., Sumová, A. Brain Res. (2005) [Pubmed]
  2. Daily rhythm and regulation of clock gene expression in the rat pineal gland. Simonneaux, V., Poirel, V.J., Garidou, M.L., Nguyen, D., Diaz-Rodriguez, E., Pévet, P. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  3. Clock gene daily profiles and their phase relationship in the rat suprachiasmatic nucleus are affected by photoperiod. Sumová, A., Jác, M., Sládek, M., Sauman, I., Illnerová, H. J. Biol. Rhythms (2003) [Pubmed]
  4. Melatonin induces Cry1 expression in the pars tuberalis of the rat. Dardente, H., Menet, J.S., Poirel, V.J., Streicher, D., Gauer, F., Vivien-Roels, B., Klosen, P., Pévet, P., Masson-Pévet, M. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  5. Circadian and photic regulation of cryptochrome mRNAs in the rat pineal gland. Nakamura, T.J., Shinohara, K., Funabashi, T., Mitsushima, D., Kimura, F. Neurosci. Res. (2001) [Pubmed]
  6. Effect of estrogen on the expression of Cry1 and Cry2 mRNAs in the suprachiasmatic nucleus of female rats. Nakamura, T.J., Shinohara, K., Funabashi, T., Kimura, F. Neurosci. Res. (2001) [Pubmed]
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