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Kcnab2  -  potassium channel, voltage-gated shaker...

Rattus norvegicus

Synonyms: Ckbeta2, K(+) channel subunit beta-2, Kcnb3, Kv-beta-2, Voltage-gated potassium channel subunit beta-2
 
 
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High impact information on Kcnab2

 

Anatomical context of Kcnab2

  • The anti-beta-subunit antibodies displayed a specific reaction on immunoblots of rat brain membranes with a major 38 kDa polypeptide, and a minor 41 kDa polypeptide, which correspond closely to the predicted sizes of the Kv beta 2 and Kv beta 1 beta-subunit polypeptides, respectively, recently cloned from rat brain [5].
  • Immunohistochemical staining using subunit-specific monoclonal and affinity-purified polyclonal antibodies revealed that the Kv beta 1 and Kv beta 2 polypeptides frequently co-localize and are concentrated in neuronal perikarya, dendrites, and terminal fields, and in the juxtaparanodal region of myelinated axons [1].
 

Analytical, diagnostic and therapeutic context of Kcnab2

  • Immunoblot and reciprocal co-immunoprecipitation analyses indicated that Kv beta 2 is the major beta subunit present in rat brain membranes, and that most K+ channel complexes containing Kv beta 1 also contain Kv beta 2 [1].
  • The purified Kv beta 2, examined by atomic force and electron microscopy techniques, is found predominately as a square-shaped tetrameric complex with side dimensions of 100 x 100 A2 and height of 51 A. Thus, Kv beta 2 is capable of forming a tetramer in the absence of pore-forming alpha subunits [6].

References

  1. Voltage-gated K+ channel beta subunits: expression and distribution of Kv beta 1 and Kv beta 2 in adult rat brain. Rhodes, K.J., Monaghan, M.M., Barrezueta, N.X., Nawoschik, S., Bekele-Arcuri, Z., Matos, M.F., Nakahira, K., Schechter, L.E., Trimmer, J.S. J. Neurosci. (1996) [Pubmed]
  2. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. Croci, C., Brändstatter, J.H., Enz, R. J. Biol. Chem. (2003) [Pubmed]
  3. Functional characterization of Kv channel beta-subunits from rat brain. Heinemann, S.H., Rettig, J., Graack, H.R., Pongs, O. J. Physiol. (Lond.) (1996) [Pubmed]
  4. Protein kinase C-mediated phosphorylation of Kv beta 2 in adult rat brain. Wang, X., Zhang, J., Berkowski, S.M., Knowleg, H., Chandramouly, A.B., Downens, M., Prystowsky, M.B. Neurochem. Res. (2004) [Pubmed]
  5. Association and colocalization of K+ channel alpha- and beta-subunit polypeptides in rat brain. Rhodes, K.J., Keilbaugh, S.A., Barrezueta, N.X., Lopez, K.L., Trimmer, J.S. J. Neurosci. (1995) [Pubmed]
  6. Images of oligomeric Kv beta 2, a modulatory subunit of potassium channels. van Huizen, R., Czajkowsky, D.M., Shi, D., Shao, Z., Li, M. FEBS Lett. (1999) [Pubmed]
 
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