The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Kcnab1  -  potassium channel, voltage-gated shaker...

Rattus norvegicus

Synonyms: K(+) channel subunit beta-1, Kv-beta-1, Kvb1, Voltage-gated potassium channel subunit beta-1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Kcnab1

  • In situ hybridization using cRNA probes revealed that these beta-subunit genes are heterogeneously expressed, with high densities of Kv beta 1 mRNA in the striatum, CA1 subfield of the hippocampus, and cerebellar Purkinje cells, and high densities of Kv beta 2 mRNA in the cerebral cortex, cerebellum, and brainstem [1].
  • One of these subunits, Kv beta 1 from rat brain, was previously demonstrated to increase the rate of inactivation of Kv1.1 and Kv1.4 when co-expressed in Xenopus oocytes [2].
  • Kv beta 1.1 induced inactivation in members of the Kv1 subfamily with the exception of Kv 1.6; no inactivation of Kv 2.1, Kv 3.4 delta 2-28 and Kv4.1 channels could be observed [3].
  • These observations suggest that Kv beta subunit expression is tissue specific and inducible in stimulated lymphocytes [4].
  • Four mRNAs were differentially expressed: Kv1.2, Kv1.4, Kv2.2 and Kv beta 1 [5].
 

Biological context of Kcnab1

 

Anatomical context of Kcnab1

  • The anti-beta-subunit antibodies displayed a specific reaction on immunoblots of rat brain membranes with a major 38 kDa polypeptide, and a minor 41 kDa polypeptide, which correspond closely to the predicted sizes of the Kv beta 2 and Kv beta 1 beta-subunit polypeptides, respectively, recently cloned from rat brain [7].
  • Immunohistochemical staining using subunit-specific monoclonal and affinity-purified polyclonal antibodies revealed that the Kv beta 1 and Kv beta 2 polypeptides frequently co-localize and are concentrated in neuronal perikarya, dendrites, and terminal fields, and in the juxtaparanodal region of myelinated axons [1].
  • The molecular basis of voltage-dependent K+ (Kv) current in smooth muscle cells (SMCs) from rat tail artery was investigated by screening transcriptional expression of 15 Kv channel alpha-subunits and 3 Kv beta-subunits using RT-PCR technique [8].
 

Regulatory relationships of Kcnab1

 

Other interactions of Kcnab1

 

Analytical, diagnostic and therapeutic context of Kcnab1

References

  1. Voltage-gated K+ channel beta subunits: expression and distribution of Kv beta 1 and Kv beta 2 in adult rat brain. Rhodes, K.J., Monaghan, M.M., Barrezueta, N.X., Nawoschik, S., Bekele-Arcuri, Z., Matos, M.F., Nakahira, K., Schechter, L.E., Trimmer, J.S. J. Neurosci. (1996) [Pubmed]
  2. A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. Morales, M.J., Castellino, R.C., Crews, A.L., Rasmusson, R.L., Strauss, H.C. J. Biol. Chem. (1995) [Pubmed]
  3. Functional characterization of Kv channel beta-subunits from rat brain. Heinemann, S.H., Rettig, J., Graack, H.R., Pongs, O. J. Physiol. (Lond.) (1996) [Pubmed]
  4. Lymphocyte-specific inducible expression of potassium channel beta subunits. Autieri, M.V., Belkowski, S.M., Constantinescu, C.S., Cohen, J.A., Prystowsky, M.B. J. Neuroimmunol. (1997) [Pubmed]
  5. Potassium channel mRNA expression in prevertebral and paravertebral sympathetic neurons. Dixon, J.E., McKinnon, D. Eur. J. Neurosci. (1996) [Pubmed]
  6. Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit. Heinemann, S.H., Rettig, J., Wunder, F., Pongs, O. FEBS Lett. (1995) [Pubmed]
  7. Association and colocalization of K+ channel alpha- and beta-subunit polypeptides in rat brain. Rhodes, K.J., Keilbaugh, S.A., Barrezueta, N.X., Lopez, K.L., Trimmer, J.S. J. Neurosci. (1995) [Pubmed]
  8. Molecular basis of voltage-dependent delayed rectifier K+ channels in smooth muscle cells from rat tail artery. Xu, C., Tang, G., Lu, Y., Wang, R. Life Sci. (2000) [Pubmed]
 
WikiGenes - Universities