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Gene Review

Kcnab1  -  potassium channel, voltage-gated shaker...

Rattus norvegicus

Synonyms: K(+) channel subunit beta-1, Kv-beta-1, Kvb1, Voltage-gated potassium channel subunit beta-1
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High impact information on Kcnab1

  • In situ hybridization using cRNA probes revealed that these beta-subunit genes are heterogeneously expressed, with high densities of Kv beta 1 mRNA in the striatum, CA1 subfield of the hippocampus, and cerebellar Purkinje cells, and high densities of Kv beta 2 mRNA in the cerebral cortex, cerebellum, and brainstem [1].
  • One of these subunits, Kv beta 1 from rat brain, was previously demonstrated to increase the rate of inactivation of Kv1.1 and Kv1.4 when co-expressed in Xenopus oocytes [2].
  • Kv beta 1.1 induced inactivation in members of the Kv1 subfamily with the exception of Kv 1.6; no inactivation of Kv 2.1, Kv 3.4 delta 2-28 and Kv4.1 channels could be observed [3].
  • These observations suggest that Kv beta subunit expression is tissue specific and inducible in stimulated lymphocytes [4].
  • Four mRNAs were differentially expressed: Kv1.2, Kv1.4, Kv2.2 and Kv beta 1 [5].

Biological context of Kcnab1


Anatomical context of Kcnab1

  • The anti-beta-subunit antibodies displayed a specific reaction on immunoblots of rat brain membranes with a major 38 kDa polypeptide, and a minor 41 kDa polypeptide, which correspond closely to the predicted sizes of the Kv beta 2 and Kv beta 1 beta-subunit polypeptides, respectively, recently cloned from rat brain [7].
  • Immunohistochemical staining using subunit-specific monoclonal and affinity-purified polyclonal antibodies revealed that the Kv beta 1 and Kv beta 2 polypeptides frequently co-localize and are concentrated in neuronal perikarya, dendrites, and terminal fields, and in the juxtaparanodal region of myelinated axons [1].
  • The molecular basis of voltage-dependent K+ (Kv) current in smooth muscle cells (SMCs) from rat tail artery was investigated by screening transcriptional expression of 15 Kv channel alpha-subunits and 3 Kv beta-subunits using RT-PCR technique [8].

Regulatory relationships of Kcnab1


Other interactions of Kcnab1


Analytical, diagnostic and therapeutic context of Kcnab1


  1. Voltage-gated K+ channel beta subunits: expression and distribution of Kv beta 1 and Kv beta 2 in adult rat brain. Rhodes, K.J., Monaghan, M.M., Barrezueta, N.X., Nawoschik, S., Bekele-Arcuri, Z., Matos, M.F., Nakahira, K., Schechter, L.E., Trimmer, J.S. J. Neurosci. (1996) [Pubmed]
  2. A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. Morales, M.J., Castellino, R.C., Crews, A.L., Rasmusson, R.L., Strauss, H.C. J. Biol. Chem. (1995) [Pubmed]
  3. Functional characterization of Kv channel beta-subunits from rat brain. Heinemann, S.H., Rettig, J., Graack, H.R., Pongs, O. J. Physiol. (Lond.) (1996) [Pubmed]
  4. Lymphocyte-specific inducible expression of potassium channel beta subunits. Autieri, M.V., Belkowski, S.M., Constantinescu, C.S., Cohen, J.A., Prystowsky, M.B. J. Neuroimmunol. (1997) [Pubmed]
  5. Potassium channel mRNA expression in prevertebral and paravertebral sympathetic neurons. Dixon, J.E., McKinnon, D. Eur. J. Neurosci. (1996) [Pubmed]
  6. Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit. Heinemann, S.H., Rettig, J., Wunder, F., Pongs, O. FEBS Lett. (1995) [Pubmed]
  7. Association and colocalization of K+ channel alpha- and beta-subunit polypeptides in rat brain. Rhodes, K.J., Keilbaugh, S.A., Barrezueta, N.X., Lopez, K.L., Trimmer, J.S. J. Neurosci. (1995) [Pubmed]
  8. Molecular basis of voltage-dependent delayed rectifier K+ channels in smooth muscle cells from rat tail artery. Xu, C., Tang, G., Lu, Y., Wang, R. Life Sci. (2000) [Pubmed]
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