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Gene Review

Sqstm1  -  sequestosome 1

Rattus norvegicus

Synonyms: Osi, PKC-zeta-interacting protein, Protein kinase C-zeta-interacting protein, Sequestosome-1, Ubiquitin-binding protein p62, ...
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High impact information on Sqstm1


Biological context of Sqstm1


Anatomical context of Sqstm1

  • Although, ZIP/p62 was not a PKC-iota substrate, the formation of a ZIP/p62-aPKC complex in PC12 cells by NGF occurred post activation of PKC-iota and was regulated by the tyrosine phosphorylation state of aPKC [6].


  1. Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. Puls, A., Schmidt, S., Grawe, F., Stabel, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. Croci, C., Brändstatter, J.H., Enz, R. J. Biol. Chem. (2003) [Pubmed]
  3. Zipper-interacting protein kinase induces Ca(2+)-free smooth muscle contraction via myosin light chain phosphorylation. Niiro, N., Ikebe, M. J. Biol. Chem. (2001) [Pubmed]
  4. Time-dependent effects of haloperidol and ziprasidone on nerve growth factor, cholinergic neurons, and spatial learning in rats. Terry, A.V., Parikh, V., Gearhart, D.A., Pillai, A., Hohnadel, E., Warner, S., Nasrallah, H.A., Mahadik, S.P. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  5. Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells. Kelleher, S.L., Lönnerdal, B. J. Nutr. (2003) [Pubmed]
  6. Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: evidence for regulation of nerve growth factor-induced differentiation. Samuels, I.S., Seibenhener, M.L., Neidigh, K.B., Wooten, M.W. J. Cell. Biochem. (2001) [Pubmed]
  7. Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions. Koskinen, P.J., Ayer, D.E., Eisenman, R.N. Cell Growth Differ. (1995) [Pubmed]
  8. Neuroscience. ZAP and ZIP, a story to forget. Bliss, T.V., Collingridge, G.L., Laroche, S. Science (2006) [Pubmed]
  9. Increased adipose tissue expression of Grb14 in several models of insulin resistance. Cariou, B., Capitaine, N., Le Marcis, V., Vega, N., Béréziat, V., Kergoat, M., Laville, M., Girard, J., Vidal, H., Burnol, A.F. FASEB J. (2004) [Pubmed]
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