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Gene Review:

CARD10 - caspase recruitment domain family, member 10

Homo sapiens

Synonyms: BIMP1, CARD-containing MAGUK protein 3, CARMA3, Carma 3, Caspase recruitment domain-containing protein 10

Stilo, R. et al., Nagao, M. et al., Sánchez-Moreno, M.J. et al., Wang, L. et al., McAllister-Lucas, L.M. et al.

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High impact information on CARD10

CARMA3/Bcl10/MALT1-dependent NF-{kappa}B activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells [1].
Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator [2].
Expression of the NEMO-binding region of CARMA3 exerts a dominant negative effect on Bcl10-mediated activation of NFkappaB [2].
Here we have shown that CARMA1 and CARMA3 physically associate with Ikappa kinase gamma/NFkappaB essential modulator (IkappaKgamma-NEMO) in lymphoid and non-lymphoid cells [2].
Finally, considering that benzimidazole as well as phosphonate derivatives are employed as therapeutic agents, the potential biological properties of Bimp, especially regarding nucleic acid polymerases, are briefly discussed [3].

Biological context of CARD10

This new method, which enables sarin's hydrolysis products to be detected in BIMP-exposed erythrocytes, is a useful tool for studying sarin-poisoning victims [4].
The ID50 and LD50 values of BIMP in mice after intravenous injection were 3.9 nM and 0.8 mg/kg, respectively [4].

Anatomical context of CARD10

We report here that CARD10 is a novel BCL10 interactor that belongs to the membrane-associated guanylate kinase family, a class of proteins that function to organize signaling complexes at plasma membranes [5].

References

CARMA3/Bcl10/MALT1-dependent NF-{kappa}B activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. McAllister-Lucas, L.M., Ruland, J., Siu, K., Jin, X., Gu, S., Kim, D.S., Kuffa, P., Kohrt, D., Mak, T.W., Nu??ez, G., Lucas, P.C. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator. Stilo, R., Liguoro, D., Di Jeso, B., Formisano, S., Consiglio, E., Leonardi, A., Vito, P. J. Biol. Chem. (2004) [Pubmed]
Metal ion-binding properties of (1H-benzimidazol-2-yl-methyl)phosphonate (Bimp2-) in aqueous solution. Isomeric equilibria, extent of chelation, and a new quantification method for the chelate effect. Sánchez-Moreno, M.J., Fernández-Botello, A., Gómez-Coca, R.B., Griesser, R., Ochocki, J., Kotynski, A., Niclós-Gutiérrez, J., Moreno, V., Sigel, H. Inorganic chemistry. (2004) [Pubmed]
Detection of sarin hydrolysis products from sarin-like organophosphorus agent-exposed human erythrocytes. Nagao, M., Takatori, T., Matsuda, Y., Nakajima, M., Niijima, H., Iwase, H., Iwadate, K., Amano, T. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. Wang, L., Guo, Y., Huang, W.J., Ke, X., Poyet, J.L., Manji, G.A., Merriam, S., Glucksmann, M.A., DiStefano, P.S., Alnemri, E.S., Bertin, J. J. Biol. Chem. (2001) [Pubmed]

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