Gene Review:
IKBKG - inhibitor of kappa light polypeptide gene...
Homo sapiens
Synonyms:
AMCBX1, FIP-3, FIP3, Fip3p, I-kappa-B kinase subunit gamma, ...
- X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Döffinger, R., Smahi, A., Bessia, C., Geissmann, F., Feinberg, J., Durandy, A., Bodemer, C., Kenwrick, S., Dupuis-Girod, S., Blanche, S., Wood, P., Rabia, S.H., Headon, D.J., Overbeek, P.A., Le Deist, F., Holland, S.M., Belani, K., Kumararatne, D.S., Fischer, A., Shapiro, R., Conley, M.E., Reimund, E., Kalhoff, H., Abinun, M., Munnich, A., Israël, A., Courtois, G., Casanova, J.L. Nat. Genet. (2001)
- Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. Li, Y., Kang, J., Friedman, J., Tarassishin, L., Ye, J., Kovalenko, A., Wallach, D., Horwitz, M.S. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. Orange, J.S., Levy, O., Brodeur, S.R., Krzewski, K., Roy, R.M., Niemela, J.E., Fleisher, T.A., Bonilla, F.A., Geha, R.S. J. Allergy Clin. Immunol. (2004)
- Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. Orange, J.S., Brodeur, S.R., Jain, A., Bonilla, F.A., Schneider, L.C., Kretschmer, R., Nurko, S., Rasmussen, W.L., Köhler, J.R., Gellis, S.E., Ferguson, B.M., Strominger, J.L., Zonana, J., Ramesh, N., Ballas, Z.K., Geha, R.S. J. Clin. Invest. (2002)
- A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO). Zonana, J., Elder, M.E., Schneider, L.C., Orlow, S.J., Moss, C., Golabi, M., Shapira, S.K., Farndon, P.A., Wara, D.W., Emmal, S.A., Ferguson, B.M. Am. J. Hum. Genet. (2000)
- Finding Nemo: Molecular phylogeny and evolution of the unusual life style of anemonefish. Santini, S., Polacco, G. Gene (2006)
- PIDD mediates NF-kappaB activation in response to DNA damage. Janssens, S., Tinel, A., Lippens, S., Tschopp, J. Cell (2005)
- IP-1: a dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation. Auwerx, J., Sassone-Corsi, P. Cell (1991)
- Sustained activation of protein kinase C downregulates nuclear factor-{kappa}B signaling by dissociation of IKK-{gamma} and Hsp90 complex in human colonic epithelial cells. Park, K.A., Byun, H.S., Won, M., Yang, K.J., Shin, S., Piao, L., Kim, J.M., Yoon, W.H., Junn, E., Park, J., Seok, J.H., Hur, G.M. Carcinogenesis (2007)
- Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-gamma). Aradhya, S., Courtois, G., Rajkovic, A., Lewis, R.A., Levy, M., Israël, A., Nelson, D.L. Am. J. Hum. Genet. (2001)
- AP-1 (Fos-Jun) regulation by IP-1: effect of signal transduction pathways and cell growth. Auwerx, J., Sassone-Corsi, P. Oncogene (1992)
- PET studies of parkinsonism associated with mutation in the alpha-synuclein gene. Samii, A., Markopoulou, K., Wszolek, Z.K., Sossi, V., Dobko, T., Mak, E., Calne, D.B., Stoessl, A.J. Neurology (1999)
- Characterization of the effect of SR48692 on inositol monophosphate, cyclic GMP and cyclic AMP responses linked to neurotensin receptor activation in neuronal and non-neuronal cells. Oury-Donat, F., Thurneyssen, O., Gonalons, N., Forgez, P., Gully, D., Le Fur, G., Soubrie, P. Br. J. Pharmacol. (1995)
- Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Zhang, S.Q., Kovalenko, A., Cantarella, G., Wallach, D. Immunity (2000)
- In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase. Carter, R.S., Pennington, K.N., Ungurait, B.J., Ballard, D.W. J. Biol. Chem. (2003)
- Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Wu, Z.H., Shi, Y., Tibbetts, R.S., Miyamoto, S. Science (2006)
- Dimerization of the I{kappa}B Kinase-Binding Domain of NEMO Is Required for Tumor Necrosis Factor Alpha-Induced NF-{kappa}B Activity. Marienfeld, R.B., Palkowitsch, L., Ghosh, S. Mol. Cell. Biol. (2006)
- Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination. Temmerman, S.T., Ma, C.A., Borges, L., Kubin, M., Liu, S., Derry, J.M., Jain, A. Blood (2006)
- The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component. Krappmann, D., Hatada, E.N., Tegethoff, S., Li, J., Klippel, A., Giese, K., Baeuerle, P.A., Scheidereit, C. J. Biol. Chem. (2000)
- Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator. Stilo, R., Liguoro, D., Di Jeso, B., Formisano, S., Consiglio, E., Leonardi, A., Vito, P. J. Biol. Chem. (2004)
- CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. Leonardi, A., Chariot, A., Claudio, E., Cunningham, K., Siebenlist, U. Proc. Natl. Acad. Sci. U.S.A. (2000)
- The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma. Saito, K., Kigawa, T., Koshiba, S., Sato, K., Matsuo, Y., Sakamoto, A., Takagi, T., Shirouzu, M., Yabuki, T., Nunokawa, E., Seki, E., Matsuda, T., Aoki, M., Miyata, Y., Hirakawa, N., Inoue, M., Terada, T., Nagase, T., Kikuno, R., Nakayama, M., Ohara, O., Tanaka, A., Yokoyama, S. Structure (Camb.) (2004)
- NEMO is a sensor of Lys 63-linked polyubiquitination and functions in NF-kappaB activation. Wu, C.J., Conze, D.B., Li, T., Srinivasula, S.M., Ashwell, J.D. Nat. Cell Biol. (2006)
- Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex. Funakoshi-Tago, M., Tago, K., Andoh, K., Sonoda, Y., Tominaga, S., Kasahara, T. J. Biochem. (2005)
- Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Ea, C.K., Deng, L., Xia, Z.P., Pineda, G., Chen, Z.J. Mol. Cell (2006)
- IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. Harhaj, E.W., Sun, S.C. J. Biol. Chem. (1999)
- Tumor necrosis factor (TNF) and phorbol ester induce TNF-related apoptosis-inducing ligand (TRAIL) under critical involvement of NF-kappa B essential modulator (NEMO)/IKKgamma. Siegmund, D., Hausser, A., Peters, N., Scheurich, P., Wajant, H. J. Biol. Chem. (2001)
- Inhibition of the NF-kappaB survival pathway via caspase-dependent cleavage of the IKK complex scaffold protein and NF-kappaB essential modulator NEMO. Frelin, C., Imbert, V., Bottero, V., Gonthier, N., Samraj, A.K., Schulze-Osthoff, K., Auberger, P., Courtois, G., Peyron, J.F. Cell Death Differ. (2008)
- Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. Chariot, A., Leonardi, A., Muller, J., Bonif, M., Brown, K., Siebenlist, U. J. Biol. Chem. (2002)
- CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. Bouchier-Hayes, L., Conroy, H., Egan, H., Adrain, C., Creagh, E.M., MacFarlane, M., Martin, S.J. J. Biol. Chem. (2001)
- IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Rothwarf, D.M., Zandi, E., Natoli, G., Karin, M. Nature (1998)
- Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK. Xiao, G., Harhaj, E.W., Sun, S.C. J. Biol. Chem. (2000)
- Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28. Jin, D.Y., Jeang, K.T. J. Biomed. Sci. (1999)