Gene Review:
MALT1 - MALT1 paracaspase
Homo sapiens
Synonyms:
IMD12, MALT lymphoma-associated translocation, MLT, MLT1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, ...
- cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. Hu, S., Du, M.Q., Park, S.M., Alcivar, A., Qu, L., Gupta, S., Tang, J., Baens, M., Ye, H., Lee, T.H., Marynen, P., Riley, J.L., Yang, X. J. Clin. Invest. (2006)
- T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Streubel, B., Lamprecht, A., Dierlamm, J., Cerroni, L., Stolte, M., Ott, G., Raderer, M., Chott, A. Blood (2003)
- API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Okabe, M., Inagaki, H., Ohshima, K., Yoshino, T., Li, C., Eimoto, T., Ueda, R., Nakamura, S. Am. J. Pathol. (2003)
- MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Sanchez-Izquierdo, D., Buchonnet, G., Siebert, R., Gascoyne, R.D., Climent, J., Karran, L., Marin, M., Blesa, D., Horsman, D., Rosenwald, A., Staudt, L.M., Albertson, D.G., Du, M.Q., Ye, H., Marynen, P., Garcia-Conde, J., Pinkel, D., Dyer, M.J., Martinez-Climent, J.A. Blood (2003)
- Clinical features and prognosis of gastric MALT lymphoma with special reference to responsiveness to H. pylori eradication and API2-MALT1 status. Nakamura, T., Seto, M., Tajika, M., Kawai, H., Yokoi, T., Yatabe, Y., Nakamura, S. Am. J. Gastroenterol. (2008)
- The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Sun, L., Deng, L., Ea, C.K., Xia, Z.P., Chen, Z.J. Mol. Cell (2004)
- Delving deeper into MALT lymphoma biology. Bertoni, F., Zucca, E. J. Clin. Invest. (2006)
- CARMA3/Bcl10/MALT1-dependent NF-{kappa}B activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. McAllister-Lucas, L.M., Ruland, J., Siu, K., Jin, X., Gu, S., Kim, D.S., Kuffa, P., Kohrt, D., Mak, T.W., Nu??ez, G., Lucas, P.C. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Bcl10 and Malt1 control lysophosphatidic acid-induced NF-{kappa}B activation and cytokine production. Klemm, S., Zimmermann, S., Peschel, C., Mak, T.W., Ruland, J. Proc. Natl. Acad. Sci. U.S.A. (2007)
- MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. Nakagawa, M., Hosokawa, Y., Yonezumi, M., Izumiyama, K., Suzuki, R., Tsuzuki, S., Asaka, M., Seto, M. Blood (2005)
- Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway. Lucas, P.C., Yonezumi, M., Inohara, N., McAllister-Lucas, L.M., Abazeed, M.E., Chen, F.F., Yamaoka, S., Seto, M., Nunez, G. J. Biol. Chem. (2001)
- MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation. Che, T., You, Y., Wang, D., Tanner, M.J., Dixit, V.M., Lin, X. J. Biol. Chem. (2004)
- MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression. Ye, H., Gong, L., Liu, H., Hamoudi, R.A., Shirali, S., Ho, L., Chott, A., Streubel, B., Siebert, R., Gesk, S., Martin-Subero, J.I., Radford, J.A., Banerjee, S., Nicholson, A.G., Ranaldi, R., Remstein, E.D., Gao, Z., Zheng, J., Isaacson, P.G., Dogan, A., Du, M.Q. J. Pathol. (2005)
- Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Morgan, J.A., Yin, Y., Borowsky, A.D., Kuo, F., Nourmand, N., Koontz, J.I., Reynolds, C., Soreng, L., Griffin, C.A., Graeme-Cook, F., Harris, N.L., Weisenburger, D., Pinkus, G.S., Fletcher, J.A., Sklar, J. Cancer Res. (1999)
- Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) arising in the small intestine with monoclonal cryoglobulinemia. Saito, T., Tamaru, J., Kishi, H., Kayao, J., Kuzuu, Y., Wakita, H., Adachi, A., Itoyama, S., Mikata, I. Pathol. Int. (2004)
- The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. Dong, W., Liu, Y., Peng, J., Chen, L., Zou, T., Xiao, H., Liu, Z., Li, W., Bu, Y., Qi, Y. J. Biol. Chem. (2006)
- Fungal bioconversion of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4-dichlorophenol (2,4-DCP). Vroumsia, T., Steiman, R., Seigle-Murandi, F., Benoit-Guyod, J.L. Chemosphere (2005)
- Marginal-zone B-cell lymphoma of extranodal mucosa-associated lymphoid tissue type: molecular genetics provides new insights into pathogenesis. Vega, F., Medeiros, L.J. Advances in anatomic pathology. (2001)
- API2-MALT1 fusion protein induces transcriptional activation of the API2 gene through NF-kappaB binding elements: evidence for a positive feed-back loop pathway resulting in unremitting NF-kappaB activation. Hosokawa, Y., Suzuki, H., Nakagawa, M., Lee, T.H., Seto, M. Biochem. Biophys. Res. Commun. (2005)
- Distinct comparative genomic hybridisation profiles in gastric mucosa-associated lymphoid tissue lymphomas with and without t(11;18)(q21;q21). Zhou, Y., Ye, H., Martin-Subero, J.I., Hamoudi, R., Lu, Y.J., Wang, R., Siebert, R., Shipley, J., Isaacson, P.G., Dogan, A., Du, M.Q. Br. J. Haematol. (2006)
- Identification of overexpressed genes in frequently gained/amplified chromosome regions in multiple myeloma. Largo, C., Alvarez, S., Saez, B., Blesa, D., Martin-Subero, J.I., González-García, I., Brieva, J.A., Dopazo, J., Siebert, R., Calasanz, M.J., Cigudosa, J.C. Haematologica (2006)
- MALT1 and BCL10 aberrations in MALT lymphomas and their effect on the expression of BCL10 in the tumour cells. Sagaert, X., Laurent, M., Baens, M., Wlodarska, I., De Wolf-Peeters, C. Mod. Pathol. (2006)
- The Bcl10/Malt1 signaling pathway as a drug target in lymphoma. Jost, P., Peschel, C., Ruland, J. Current drug targets. (2006)
- API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products. Motegi, M., Yonezumi, M., Suzuki, H., Suzuki, R., Hosokawa, Y., Hosaka, S., Kodera, Y., Morishima, Y., Nakamura, S., Seto, M. Am. J. Pathol. (2000)
- Heterogeneous copy numbers of API2-MALT1 chimeric transcripts in mucosa-associated lymphoid tissue lymphoma. Suguro-Katayama, M., Suzuki, R., Kasugai, Y., Nakamura, T., Suzuki, H., Hosokawa, Y., Shiku, H., Nakamura, S., Seto, M. Leukemia (2003)
- The API2/MALT1 fusion product may lead to germinal center B cell lymphomas by suppression of apoptosis. Stoffel, A., Le Beau, M.M. Hum. Hered. (2001)