Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Galt - galactose-1-phosphate uridylyltransferase

Rattus norvegicus

Synonyms: Gal-1-P uridylyltransferase, Galactose-1-phosphate uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase

Weckbecker, G. et al., Komuniecki, R.W. et al., Heidenreich, R.A. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Galt

Galactosemia is an inborn error of metabolism in humans due to deficient activity of the enzyme galactose-1-phosphate uridyl-transferase (GALT) [1].

High impact information on Galt

Km and V values in a range comparable to that of the respective UDP-sugars were determined for FUDP-sugars in the reactions catalyzed by UDP-glucose pyrophosphorylase, galactose-1-phosphate uridylyltransferase, UDP-glucose 4-epimerase, UDP-N-acetylglucosamine 2-epimerase, glycogen synthase, and UDP-glucose dehydrogenase [2].
1. Crude enzyme preparations from Hymenolepis diminuta contained galactokinase, galactose 1-phosphate uridyl transferase and UDPgalactose 4-epimerase activity, although their specific activities were low [3].

References

Rat galactose-1-phosphate uridyltransferase coding sequence, transcription start site and genomic organization. Heidenreich, R.A., Mallee, J., Segal, S. DNA Seq. (1993) [Pubmed]
Substrate properties of 5-fluorouridine diphospho sugars detected in hepatoma cells. Weckbecker, G., Keppler, D.O. Biochem. Pharmacol. (1984) [Pubmed]
Enzymes of galactose utilization in the rat tapeworm, Hymenolepis diminuta. Komuniecki, R.W., Roberts, L.S. Comp. Biochem. Physiol., B (1977) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP004451	Anopheles gambiae str. PEST
GALT	Bos taurus
ZK1058.3	Caenorhabditis elegans
GALT	Canis lupus familiaris
galt	Danio rerio
Galt	Drosophila melanogaster
GALT	Gallus gallus
GALT	Homo sapiens
KLLA0F08437g	Kluyveromyces lactis NRRL Y-1140
MGG_05098	Magnaporthe oryzae 70-15
Galt	Mus musculus
NCU04460	Neurospora crassa OR74A
GALT	Pan troglodytes
GAL7	Saccharomyces cerevisiae S288c
gal7	Schizosaccharomyces pombe 972h-
galt	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.