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Gene Review

GALT  -  galactose-1-phosphate uridylyltransferase

Bos taurus

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Disease relevance of GALT

  • The GALT-primed calves received an ID dose of live Pasteurella haemolytica A1 followed by a subcutaneous (SC) dose of killed P. haemolytica [1].
  • Following oral vaccination with BCG, the organisms were localised and persisted in GALT but did not spread to the spleen, liver or lungs [2].
  • AIMS: To determine immune responses, and the localisation and persistence of Mycobacterium bovis bacille Calmette-Guérin (BCG) in gut-associated lymphoid tissues (GALT) and other organs in possums vaccinated orally with lipid-formulated BCG vaccine [2].

High impact information on GALT

  • This suggests that early digestion is negatively correlated to the IgA antibody response and that the IgA response associated to the gut associated lymphoid tissue (GALT) and the systemic IgG antibody responses are independent [3].
  • The amounts of biliary antibodies generated by the parenteral injection of antigen and adjuvant were comparable to those that occurred after the same materials were injected directly into the GALT [4].
  • GALT lymphocytes were isolated and counted [5].
  • After proteinase K (PK) pretreatment, abnormal PrP was still detectable only in the gut-associated lymphoid tissue (GALT) of clinically affected mice and, to a much more limited degree, in the enteric nervous system (ENS) [6].
  • In cattle with late onset MD, lesions in the oral cavity were generally milder and in the intestinal tract they were not only associated with GALT, but frequently affected the mucosa outside [7].

Anatomical context of GALT


Analytical, diagnostic and therapeutic context of GALT

  • The GALT-primed calves had increased serum IgG, lavage IgG and IgA and increased LNA titers in both lavage fluids and serum following the SC dose of killed bacteria [1].


  1. Induction of pulmonary antibodies to Pasteurella haemolytica following intraduodenal stimulation of the gut-associated lymphatic tissue in cattle. Bowersock, T.L., Walker, R.D., McCracken, M.D., Hopkins, F.M., Moore, R.N. Can. J. Vet. Res. (1989) [Pubmed]
  2. Oral vaccination of brushtail possums (Tichosurus vulpecula) with BCG: immune responses, persistence of BCG in lymphoid organs and excretion in faeces. Wedlock, D.N., Aldwell, F.E., Keen, D., Skinner, M.A., Buddle, B.M. New Zealand veterinary journal. (2005) [Pubmed]
  3. Differential binding of IgG and IgA antibodies to antigenic determinants of bovine serum albumin. Hilger, C., Grigioni, F., De Beaufort, C., Michel, G., Freilinger, J., Hentges, F. Clin. Exp. Immunol. (2001) [Pubmed]
  4. Studies on the adjuvant action of beryllium. II. Systemic effects with particular reference to secretory immunity. Hall, J.G., Spencer, J. Immunology (1984) [Pubmed]
  5. Albumin infusion after reperfusion prevents gut ischemia-reperfusion-induced gut-associated lymphoid tissue atrophy. Ikezawa, F., Fukatsu, K., Moriya, T., Maeshima, Y., Okamoto, K., Hara, E., Hiraide, H., Compher, C.W. JPEN. Journal of parenteral and enteral nutrition. (2006) [Pubmed]
  6. Expression of prion protein in the gut of mice infected orally with the 301V murine strain of the bovine spongiform encephalopathy agent. González, L., Terry, L., Jeffrey, M. J. Comp. Pathol. (2005) [Pubmed]
  7. Comparative investigation of tissue alterations and distribution of BVD-viral antigen in cattle with early onset versus late onset mucosal disease. Liebler-Tenorio, E.M., Lanwehr, A., Greiser-Wilke, I., Loehr, B.I., Pohlenz, J. Vet. Microbiol. (2000) [Pubmed]
  8. Gut-associated lymphoid tissue in the large intestine of calves. I. Distribution and histology. Liebler, E.M., Pohlenz, J.F., Woode, G.N. Vet. Pathol. (1988) [Pubmed]
  9. Studies on the uptake of tomato lectin nanoparticles in everted gut sacs. Carreno-Gómez, B., Woodley, J.F., Florence, A.T. International journal of pharmaceutics. (1999) [Pubmed]
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