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Gene Review

Ugdh  -  UDP-glucose 6-dehydrogenase

Rattus norvegicus

Synonyms: UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH
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High impact information on Ugdh


Biological context of Ugdh


Anatomical context of Ugdh

  • The flavonoids also offered strong inhibition of UDP-glucose dehydrogenase (UDP-GDH) activity in the liver cytosolic fraction while the activity in hepatocytes was not affected even after 4 hr of incubation [7].

Associations of Ugdh with chemical compounds


Other interactions of Ugdh


Analytical, diagnostic and therapeutic context of Ugdh


  1. Stimulation by secretin of bilirubin UDP-glycosyltransferase activities and of cytochrome P-450 concentration in rat liver. Ricci, G.L., Fevery, J. Biochem. J. (1979) [Pubmed]
  2. Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine. Reen, R.K., Jamwal, D.S., Taneja, S.C., Koul, J.L., Dubey, R.K., Wiebel, F.J., Singh, J. Biochem. Pharmacol. (1993) [Pubmed]
  3. Enhancement of UDP-glucuronyltransferase, UDP-glucose dehydrogenase, and glutathione S-transferase activities in rat liver by dietary administration of eugenol. Yokota, H., Hashimoto, H., Motoya, M., Yuasa, A. Biochem. Pharmacol. (1988) [Pubmed]
  4. The effect of aldose reductase inhibitor Statil (ICI 128436) on the glucose over-utilization in kidney of diabetic rats. Sochor, M., Kunjara, S., McLean, P. Biochem. Pharmacol. (1988) [Pubmed]
  5. Hepatic UDP-glucuronic acid regulation during acetaminophen biotransformation in rats. Hjelle, J.J. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  6. Changes in some hepatic enzyme activities related to phase II drug metabolism in male and female rats as a function of age. Santa Maria, C., Machado, A. Mech. Ageing Dev. (1988) [Pubmed]
  7. Effects of silymarin on UDP-glucuronic acid and glucuronidation activity in the rat isolated hepatocytes and liver in relation to D-galactosamine toxicity. Chrungoo, V.J., Reen, R.K., Singh, K., Singh, J. Indian J. Exp. Biol. (1997) [Pubmed]
  8. Effects of adenosine on glucuronidation and uridine diphosphate glucuronic acid (UDPGA) synthesis in isolated rat hepatocytes. Shipley, L.A., Weiner, M. Biochem. Pharmacol. (1987) [Pubmed]
  9. Mechanisms behind the inhibitory effect of ethanol on the conjugation of morphine in rat hepatocytes. Bodd, E., Gadeholt, G., Christensson, P.I., Mørland, J. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  10. Diminished rates of glucuronidation and sulfation in perfused rat liver after chronic ethanol administration. Reinke, L.A., Moyer, M.J., Notley, K.A. Biochem. Pharmacol. (1986) [Pubmed]
  11. Substrate properties of 5-fluorouridine diphospho sugars detected in hepatoma cells. Weckbecker, G., Keppler, D.O. Biochem. Pharmacol. (1984) [Pubmed]
  12. The effect of trans-stilbene oxide and other structurally related inducers of drug-metabolizing enzymes on glucuronidation. Seidegård, J., DePierre, J.W. Chem. Biol. Interact. (1982) [Pubmed]
  13. Characterization of selective induction and alteration of xenobiotic biotransforming enzymes by vanadium during diethylnitrosamine-induced chemical rat liver carcinogenesis. Bishayee, A., Roy, S., Chatterjee, M. Oncol. Res. (1999) [Pubmed]
  14. The effect of dietary protein quantity on the activity of UDP-glucuronyltransferase and its physiological significance in drug metabolism. Merrill, J.C., Bray, T.M. Can. J. Physiol. Pharmacol. (1982) [Pubmed]
  15. Ascorbic acid in thyroidectomized rats. II) Ascorbic acid status of the storage tissues and hepatic biosynthesis of glucuronic acid. Nath, N., Nath, M., Muddeshwar, M.G. Acta Vitaminol. Enzymol. (1984) [Pubmed]
  16. Increased activity of hepatic UDP-glucose dehydrogenase after treatment of rats with trans-stilbene oxide. Seidegård, J., DePierre, J.W., Ernster, L. Acta Chem. Scand., B, Org. Chem. Biochem. (1980) [Pubmed]
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