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Gene Review

Galk1  -  galactokinase 1

Rattus norvegicus

Synonyms: Galk, Glk
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Disease relevance of Galk1


High impact information on Galk1


Biological context of Galk1


Anatomical context of Galk1


Associations of Galk1 with chemical compounds

  • As part of a series of studies to assess the regulation of hepatic galactose-metabolizing enzymes, galactokinase, galactose-1-phosphate uridyltransferase, and UDPgalactose-4-epimerase, the effect of feeding a high galactose-containing diet to normal adult and pregnant female rats was examined [10].
  • Comparison of the activities of the three liver enzymes in suckling tammar wallabies with those in suckling rats showed no difference between the two species in regard to galactokinase and uridylyl transferase, but the UDPglucose 4-epimerase activity in tammar wallabies was approximately double than found in rats [11].
  • The specific activities of the galactose-metabolizing enzymes, galactokinase (EC, galactose-1-phosphate uridyltransferase (EC, and UDPgalactose 4-epimerase (EC, in suckling-rat livers perfused for 90 min with 1 and 4 mM galactose fluctuate significantly with a different pattern of change for each enzyme [12].

Other interactions of Galk1


  1. The protective effect of L-cysteine and glutathione on the adult and aged rat brain (Na+,K+)-ATPase and Mg2+-ATPase activities in galactosemia in vitro. Tsakiris, S., Carageorgiou, H., Schulpis, K.H. Metabolic brain disease. (2005) [Pubmed]
  2. Alterations of D-galactose metabolism in Morris hepatomas. Bauer, C.H., Büchsel, R., Morris, H.P., Reutter, W.G. Cancer Res. (1980) [Pubmed]
  3. Orotate decreases the inhibitory effect of ethanol on galactose elimination in the perfused rat liver. Keiding, S., Vinterby, A. Biochem. J. (1976) [Pubmed]
  4. Microarray analysis of retinoid-dependent gene activity during rat embryogenesis: increased collagen fibril production in a model of retinoid insufficiency. Flentke, G.R., Baker, M.W., Docterman, K.E., Power, S., Lough, J., Smith, S.M. Dev. Dyn. (2004) [Pubmed]
  5. Activity of hepatic galactose-metabolizing enzymes in the pregnant rat and fetus. Rogers, S.R., Bovee, B.W., Saunders, S.L., Segal, S. Pediatr. Res. (1989) [Pubmed]
  6. Inhibitors of glycoprotein biosynthesis. Reutter, W., Bauer, C. Adv. Enzyme Regul. (1985) [Pubmed]
  7. Estimates and implications of co-operativity for enzyme kinetics in the intact liver: method of flow invariants. Bass, L. J. Theor. Biol. (1983) [Pubmed]
  8. Suckling rat brain regional distribution of Na+,K+-atpase activity in the in vitro galactosaemia: the effect of L-cysteine and glutathione. Marinou, K., Tsakiris, S., Tsopanakis, C., Schulpis, K.H., Behrakis, P. Metabolic brain disease. (2005) [Pubmed]
  9. Hexose metabolism in pancreatic islets. Galactose transport, phosphorylation and oxidation. Giroix, M.H., Malaisse-Lagae, F., Sener, A., Malaisse, W.J. Mol. Cell. Biochem. (1985) [Pubmed]
  10. Galactose as a regulatory factor of its own metabolism by rat liver. Rogers, S.R., Bovee, B.W., Saunders, S.L., Segal, S. Metab. Clin. Exp. (1989) [Pubmed]
  11. Enzymes of galactose metabolism in livers of suckling and adult tammar wallabies (Macropus eugenii) and other marsupials. Vernon, J.K., Messer, M., Green, B. Aust. J. Biol. Sci. (1981) [Pubmed]
  12. Changing activities of galactose-metabolizing enzymes during perfusion of suckling-rat liver. Rogers, S., Segal, S. Am. J. Physiol. (1981) [Pubmed]
  13. Developmental aspects of galactose-1-phosphate uridylytransferase in rat intestine. Koo, C., Rogers, S., Segal, S. Biol. Neonate (1975) [Pubmed]
  14. Enzymes of galactose utilization in the rat tapeworm, Hymenolepis diminuta. Komuniecki, R.W., Roberts, L.S. Comp. Biochem. Physiol., B (1977) [Pubmed]
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