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Gene Review

Pmm1  -  phosphomannomutase 1

Mus musculus

Synonyms: C77612, PMM 1, Phosphomannomutase 1, Secp53 (yeast) homolog
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High impact information on Pmm1


Biological context of Pmm1

  • The Pmm1 gene is composed of eight exons and spans approximately 9.5 kb [4].

Associations of Pmm1 with chemical compounds

  • Mannose supplements had little effect on the specific activity of phosphomannomutase (Man-6-P<-->Man-1-P) in different organs, but specific activity of PMI in brain, intestine, muscle, heart and lung gradually increased <2-fold with increasing mannose intake [5].

Other interactions of Pmm1

  • We compared the expression profile of the murine Pmm1 and Pmm2 mRNA and protein in prenatal and postnatal mouse brain at the histological level [3].


  1. Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants. Garami, A., Mehlert, A., Ilg, T. Mol. Cell. Biol. (2001) [Pubmed]
  2. Characterization of a granule-independent lytic mechanism used by CTL hybridomas. Garner, R., Helgason, C.D., Atkinson, E.A., Pinkoski, M.J., Ostergaard, H.L., Sorensen, O., Fu, A., Lapchak, P.H., Rabinovitch, A., McElhaney, J.E. J. Immunol. (1994) [Pubmed]
  3. Tissue distribution of the murine phosphomannomutases Pmm1 and Pmm2 during brain development. Cromphout, K., Keldermans, L., Snellinx, A., Collet, J.F., Grünewald, S., De Geest, N., Sciot, R., Vanschaftingen, E., Jaeken, J., Matthijs, G., Hartmann, D. Eur. J. Neurosci. (2005) [Pubmed]
  4. Identification and localization of two mouse phosphomannomutase genes, Pmm1 and Pmm2. Heykants, L., Schollen, E., Grünewald, S., Matthijs, G. Gene (2001) [Pubmed]
  5. Studies of mannose metabolism and effects of long-term mannose ingestion in the mouse. Davis, J.A., Freeze, H.H. Biochim. Biophys. Acta (2001) [Pubmed]
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