High impact information on Pmm1

• Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants [1].
• In this report we characterize the mechanism of killing used by two cytolytic hybridomas (PMM-1 and MD90) that express neither perforin nor the granzymes [2].
• With the use of L1210 and an L1210 cell line transfected with Fas cDNA we demonstrated that these MD90 and PMM-1 kill the latter much more effectively and that this increase was effectively inhibited with anti-Fas Ab [2].
• Tissue distribution of the murine phosphomannomutases Pmm1 and Pmm2 during brain development [3].
• Pmm1 maps to mouse chromosome 15, Pmm2 to chromosome 16 [4].

Biological context of Pmm1

• The Pmm1 gene is composed of eight exons and spans approximately 9.5 kb [4].

Associations of Pmm1 with chemical compounds

• Mannose supplements had little effect on the specific activity of phosphomannomutase (Man-6-P<-->Man-1-P) in different organs, but specific activity of PMI in brain, intestine, muscle, heart and lung gradually increased <2-fold with increasing mannose intake [5].

Other interactions of Pmm1

• We compared the expression profile of the murine Pmm1 and Pmm2 mRNA and protein in prenatal and postnatal mouse brain at the histological level [3].

References