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Chemical Compound Review

mannose     (3S,4S,5S,6R)-6- (hydroxymethyl)oxane-2,3,4...

Synonyms: Seminose, Carubinose, mannopyranose, D-mannose, DL-Mannose, ...
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Disease relevance of dextrose


High impact information on dextrose


Chemical compound and disease context of dextrose


Biological context of dextrose


Anatomical context of dextrose


Associations of dextrose with other chemical compounds


Gene context of dextrose

  • Mannose (or mannan)-binding lectin (MBL) is an oligomeric serum lectin that plays a role in innate immunity by activating the complement system [30].
  • Mannose was phosphorylated well by HXK1, but at a much lower rate by HXK2 [31].
  • Large cells, differentiated after seven days of culture, expressed high levels of MHC II molecules and Mannose Receptor, variable levels of CD80 and CD86, and low levels of CD1a [32].
  • Mannose also inhibited the expression of MT1-MMP mRNA induced by ConA [33].
  • Mannose 6-phosphate modification of wild-type and mutant PPT enzymes was grossly normal at the level of the phosphotransferase reaction [34].
  • We found that di-acylated LM inhibition of LPS-induced tumor necrosis factor secretion by murine macrophages was independent of TLR2, mannose receptor, or the murine ortholog SIGNR1 [35].

Analytical, diagnostic and therapeutic context of dextrose


  1. Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster. Chen, J.J., Zhu, Z., Gershon, A.A., Gershon, M.D. Cell (2004) [Pubmed]
  2. Mannose-sensitive and Gal-Gal binding Escherichia coli pili from recombinant strains. Chemical, functional, and serological properties. O'Hanley, P., Lark, D., Normark, S., Falkow, S., Schoolnik, G.K. J. Exp. Med. (1983) [Pubmed]
  3. Mannose-binding protein and susceptibility to chronic hepatitis B infection. Ezekowitz, A. Lancet (1996) [Pubmed]
  4. Mannose-resistant haemagglutination and P antigen recognition are characteristic of Escherichia coli causing primary pyelonephritis. Väisänen, V., Elo, J., Tallgren, L.G., Siitonen, A., Mäkelä, P.H., Svanborg-Edén, C., Källenius, G., Svenson, S.B., Hultberg, H., Korhonen, T. Lancet (1981) [Pubmed]
  5. Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts. Glickman, J.N., Kornfeld, S. J. Cell Biol. (1993) [Pubmed]
  6. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Motyka, B., Korbutt, G., Pinkoski, M.J., Heibein, J.A., Caputo, A., Hobman, M., Barry, M., Shostak, I., Sawchuk, T., Holmes, C.F., Gauldie, J., Bleackley, R.C. Cell (2000) [Pubmed]
  7. Selective recycling of the mannose 6-phosphate/IGF-II receptor to the trans Golgi network in vitro. Goda, Y., Pfeffer, S.R. Cell (1988) [Pubmed]
  8. The honeybee syndrome - implications of the teratogenicity of mannose in rat-embryo culture. Freinkel, N., Lewis, N.J., Akazawa, S., Roth, S.I., Gorman, L. N. Engl. J. Med. (1984) [Pubmed]
  9. Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor. Tenner, A.J., Robinson, S.L., Ezekowitz, R.A. Immunity (1995) [Pubmed]
  10. Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium. Irjala, H., Johansson, E.L., Grenman, R., Alanen, K., Salmi, M., Jalkanen, S. J. Exp. Med. (2001) [Pubmed]
  11. Mannose-sensitive and mannose-resistant adherence to human uroepithelial cells and urinary virulence of Escherichia coli. van der Bosch, J.F., Verboom-Sohmer, U., Postma, P., de Graaff, J., MacLaren, D.M. Infect. Immun. (1980) [Pubmed]
  12. Use of specific sugars to inhibit bacterial adherence to equine endometrium in vitro. King, S.S., Young, D.A., Nequin, L.G., Carnevale, E.M. Am. J. Vet. Res. (2000) [Pubmed]
  13. Mannose inhibition of Escherichia coli adherence to urinary bladder epithelium: comparison with yeast agglutination. Ruggieri, M.R., Hanno, P.M., Levin, R.M. Urol. Res. (1985) [Pubmed]
  14. Mannose binding protein gene mutations associated with unusual and severe infections in adults. Summerfield, J.A., Ryder, S., Sumiya, M., Thursz, M., Gorchein, A., Monteil, M.A., Turner, M.W. Lancet (1995) [Pubmed]
  15. Mannose-binding protein genotypes and recurrent infection. Snowden, N., Stanworth, S., Donn, R., Davies, E., Ollier, B. Lancet (1995) [Pubmed]
  16. Mannose 6-phosphate receptor-mediated endocytosis of acid hydrolases: internalization of beta-glucuronidase is accompanied by a limited dephosphorylation. Gabel, C.A., Foster, S.A. J. Cell Biol. (1986) [Pubmed]
  17. Pel, the protein that permits lambda DNA penetration of Escherichia coli, is encoded by a gene in ptsM and is required for mannose utilization by the phosphotransferase system. Williams, N., Fox, D.K., Shea, C., Roseman, S. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  18. Growth-dependent alterations in oligomannosyl cores of glycopeptides. Ceccarini, C., Muramatsu, T., Tsang, J., Atkinson, P.H. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  19. Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes? Braulke, T., Gartung, C., Hasilik, A., von Figura, K. J. Cell Biol. (1987) [Pubmed]
  20. Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction. Nykjaer, A., Christensen, E.I., Vorum, H., Hager, H., Petersen, C.M., Røigaard, H., Min, H.Y., Vilhardt, F., Møller, L.B., Kornfeld, S., Gliemann, J. J. Cell Biol. (1998) [Pubmed]
  21. The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vital. Gentzsch, M., Tanner, W. EMBO J. (1996) [Pubmed]
  22. Mannose-specific endocytosis receptor of alveolar macrophages: demonstration of two functionally distinct intracellular pools of receptor and their roles in receptor recycling. Tietze, C., Schlesinger, P., Stahl, P. J. Cell Biol. (1982) [Pubmed]
  23. Mannose receptor regulates myoblast motility and muscle growth. Jansen, K.M., Pavlath, G.K. J. Cell Biol. (2006) [Pubmed]
  24. Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis. Further evidence for a role for inositol phosphate-oligosaccharides in insulin action. Machicao, F., Mushack, J., Seffer, E., Ermel, B., Häring, H.U. Biochem. J. (1990) [Pubmed]
  25. Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation. Willenborg, M., Schmidt, C.K., Braun, P., Landgrebe, J., von Figura, K., Saftig, P., Eskelinen, E.L. J. Lipid Res. (2005) [Pubmed]
  26. Mono- and bivalent ligands bearing mannose 6-phosphate (M6P) surrogates: targeting the M6P/insulin-like growth factor II receptor. Berkowitz, D.B., Maiti, G., Charette, B.D., Dreis, C.D., MacDonald, R.G. Org. Lett. (2004) [Pubmed]
  27. Three-dimensional structures of complexes of Lathyrus ochrus isolectin I with glucose and mannose: fine specificity of the monosaccharide-binding site. Bourne, Y., Roussel, A., Frey, M., Rougé, P., Fontecilla-Camps, J.C., Cambillau, C. Proteins (1990) [Pubmed]
  28. Glycoprotein Hypersecretion Alters the Cell Wall in Trichoderma reesei Strains Expressing the Saccharomyces cerevisiae Dolichylphosphate Mannose Synthase Gene. Perlinska-Lenart, U., Orlowski, J., Laudy, A.E., Zdebska, E., Palamarczyk, G., Kruszewska, J.S. Appl. Environ. Microbiol. (2006) [Pubmed]
  29. The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor. Malovic, I., Sørensen, K.K., Elvevold, K.H., Nedredal, G.I., Paulsen, S., Erofeev, A.V., Smedsrød, B.H., McCourt, P.A. Hepatology (2007) [Pubmed]
  30. Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Matsushita, M., Thiel, S., Jensenius, J.C., Terai, I., Fujita, T. J. Immunol. (2000) [Pubmed]
  31. Differences in substrate specificity and kinetic properties of the recombinant hexokinases HXK1 and HXK2 from Entamoeba histolytica. Kroschewski, H., Ortner, S., Steipe, B., Scheiner, O., Wiedermann, G., Duchêne, M. Mol. Biochem. Parasitol. (2000) [Pubmed]
  32. Commitment of juvenile myelo-monocytic (JMML) leukemic cells to spontaneously differentiate into dendritic cells. Longoni, D., D'Amico, G., Gaipa, G., Bernasconi, S., Vulcano, M., Onnis, P., Niemeyer, C.M., Allavena, P., Biondi, A. Hematol. J. (2002) [Pubmed]
  33. Carbohydrate-mediated regulation of matrix metalloproteinase-2 activation in normal human fibroblasts and fibrosarcoma cells. Gervasi, D.C., Raz, A., Dehem, M., Yang, M., Kurkinen, M., Fridman, R. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  34. Biochemical analysis of mutations in palmitoyl-protein thioesterase causing infantile and late-onset forms of neuronal ceroid lipofuscinosis. Das, A.K., Lu, J.Y., Hofmann, S.L. Hum. Mol. Genet. (2001) [Pubmed]
  35. Acylation determines the toll-like receptor (TLR)-dependent positive versus TLR2-, mannose receptor-, and SIGNR1-independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannan. Doz, E., Rose, S., Nigou, J., Gilleron, M., Puzo, G., Erard, F., Ryffel, B., Quesniaux, V.F. J. Biol. Chem. (2007) [Pubmed]
  36. The major lung surfactant protein, SP 28-36, is a calcium-dependent, carbohydrate-binding protein. Haagsman, H.P., Hawgood, S., Sargeant, T., Buckley, D., White, R.T., Drickamer, K., Benson, B.J. J. Biol. Chem. (1987) [Pubmed]
  37. Delayed activation of the mannose receptor following synthesis. Requirement for exit from the endoplasmic reticulum. Pontow, S.E., Blum, J.S., Stahl, P.D. J. Biol. Chem. (1996) [Pubmed]
  38. The role of the membrane in the regulation of activity of microsomal glucose-6-phosphatase. Zakim, D., Edmondson, D.E. J. Biol. Chem. (1982) [Pubmed]
  39. Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury. Walsh, M.C., Bourcier, T., Takahashi, K., Shi, L., Busche, M.N., Rother, R.P., Solomon, S.D., Ezekowitz, R.A., Stahl, G.L. J. Immunol. (2005) [Pubmed]
  40. Susceptibility of porcine intestine to pilus-mediated adhesion by some isolates of piliated enterotoxigenic Escherichia coli increases with age. Nagy, B., Casey, T.A., Whipp, S.C., Moon, H.W. Infect. Immun. (1992) [Pubmed]
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