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Gene Review

wnt5b  -  wingless-type MMTV integration site family...

Danio rerio

Synonyms: CHUNP6928, Protein Wnt-5b, SO:0000704, id:ibd5111, ppt, ...
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High impact information on wnt5b

  • We describe genetic interaction between two Wnt/Ca2+ members, Wnt-5 (pipetail) and Wnt-11 (silberblick), and a reduction of Ca2+ release in Wnt-5/pipetail [1].
  • Here, we investigated whether genes that regulate cell movements during gastrulation [no tail (ntl)/brachyury, knypek (kny) and pipetail (ppt)/wnt5] interact to regulate posterior body morphogenesis [2].
  • Abrogation of Pk1 function by morpholino oligonucleotides leads to defective convergent extension movements, enhances the silberblick (slb)/wnt11 and pipetail (Ppt)/wnt5 phenotypes and suppresses the ability of Wnt11 to rescue the slb phenotype [3].
  • In pipetail mutants, the tailbud fails to move ventrally on the yolk sac after germ ring closure, and the tip of the tail fails to detach from the yolk tube [4].
  • Here, we show that morpholino (MO)-mediated double knock-down of the Fyn and Yes tyrosine kinases in zebrafish embryos impaired normal CE cell movements, resembling the silberblick and pipetail mutants, caused by mutations in wnt11 and wnt5, respectively [5].

Biological context of wnt5b

  • The pipetail mutant phenotype is characterized by defects in tail formation and impaired maturation of the cells that contribute to cartilaginous elements of the head skeleton [6].

Other interactions of wnt5b

  • To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided and zygotically expressed at all stages during gastrulation [7].
  • Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations [8].


  1. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. Westfall, T.A., Brimeyer, R., Twedt, J., Gladon, J., Olberding, A., Furutani-Seiki, M., Slusarski, D.C. J. Cell Biol. (2003) [Pubmed]
  2. No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish. Marlow, F., Gonzalez, E.M., Yin, C., Rojo, C., Solnica-Krezel, L. Development (2004) [Pubmed]
  3. Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Carreira-Barbosa, F., Concha, M.L., Takeuchi, M., Ueno, N., Wilson, S.W., Tada, M. Development (2003) [Pubmed]
  4. Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., Nüsslein-Volhard, C. Development (1996) [Pubmed]
  5. Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements. Jopling, C., den Hertog, J. EMBO Rep. (2005) [Pubmed]
  6. Wnt5 is required for tail formation in the zebrafish embryo. Rauch, G.J., Hammerschmidt, M., Blader, P., Schauerte, H.E., Strähle, U., Ingham, P.W., McMahon, A.P., Haffter, P. Cold Spring Harb. Symp. Quant. Biol. (1997) [Pubmed]
  7. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Kilian, B., Mansukoski, H., Barbosa, F.C., Ulrich, F., Tada, M., Heisenberg, C.P. Mech. Dev. (2003) [Pubmed]
  8. Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations. Lele, Z., Bakkers, J., Hammerschmidt, M. Genesis (2001) [Pubmed]
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