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Gene Review:

WNT5B - wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-5b

Saitoh, T. et al., Saitoh, T. et al., Kanazawa, A. et al., Katoh, M. et al.

Katoh, Katoh,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of WNT5B

WNT5A, but not WNT5B, was up-regulated by TNFalpha in MKN45 cells derived from gastric cancer [1].
Among 7 pancreatic cancer cell lines, WNT5A was up-regulated in Hs700T, and WNT5B in PANC-1 [1].
WNT5B, but not WNT5A, was up-regulated by beta-estradiol in MCF-7 cells derived from breast cancer [1].
WNT5A was relatively highly expressed in TE6 and TE10 among 12 esophageal cancer cell lines, and WNT5B was expressed in the majority of esophageal cancer cell lines [1].
Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes [2].

High impact information on WNT5B

These results indicate that the WNT5B gene may contribute to conferring susceptibility to type 2 diabetes and may be involved in the pathogenesis of this disease through the regulation of adipocyte function [2].
WNT5B showed 80.5% total-amino-acid identity with WNT5A [3].
Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region [3].
Comparison between nucleotide sequence of WNT5B cDNA and human genome draft sequences revealed that the WNT5B gene, consisting of 4 exons, was located on human chromosome 12p13.3 region [3].
Among human cancer cell lines, WNT5B was expressed in gastric cancer cell lines MKN7, MKN45, KATO-III, and a teratocarcinoma cell line NT2 [3].

Biological context of WNT5B

WNT5B encoded a 359-amino-acid polypeptide with the N-terminal signal peptide, four N-linked glycosylation sites, and consensus amino-acid residues conserved among the WNT family [3].
WNT5A gene at chromosome 3p14.3 and WNT5B gene at chromosome 12p13.33 are paralogs within the human genome [4].

Anatomical context of WNT5B

WNT5A and WNT5B were expressed together in 5 embryonal tumor cell lines, and were slightly down-regulated by all-trans retinoic acid in NT2 cells [1].
WNT5B was moderately expressed in adult prostate and fetal brain, and weakly expressed in fetal lung, kidney, adult liver, ovary, and small intestine [3].

Analytical, diagnostic and therapeutic context of WNT5B

Northern blot analyses with W5B2 probe detected the 2.8- and 2.4-kb WNT5B mRNAs [3].

References

Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells. Saitoh, T., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes. Kanazawa, A., Tsukada, S., Sekine, A., Tsunoda, T., Takahashi, A., Kashiwagi, A., Tanaka, Y., Babazono, T., Matsuda, M., Kaku, K., Iwamoto, Y., Kawamori, R., Kikkawa, R., Nakamura, Y., Maeda, S. Am. J. Hum. Genet. (2004) [Pubmed]
Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region. Saitoh, T., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
Comparative genomics on Wnt5a and Wnt5b genes. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]

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AgaP_AGAP010290	Anopheles gambiae str. PEST
WNT5B	Bos taurus
cwn-2	Caenorhabditis elegans
WNT5B	Canis lupus familiaris
wnt5b	Danio rerio
WNT5B	Gallus gallus
LOC721685	Macaca mulatta
Wnt5b	Mus musculus
WNT5B	Pan troglodytes
Wnt5b	Rattus norvegicus
wnt5b	Xenopus (Silurana) tropicalis

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