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Gene Review

fli1a  -  Fli-1 proto-oncogene, ETS transcription...

Danio rerio

Synonyms: SO:0000704, cb855, fli, fli-1, fli1, ...
 
 
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High impact information on fli1a

  • We find that the zebrafish fli1 promoter is able to drive expression of enhanced green fluorescent protein (EGFP) in all blood vessels throughout embryogenesis [1].
  • The transcription factors fli-1 and Nkx-2.5 are expressed asymmetrically in the precardiac mesoderm and subsequently in the heart; an Eph receptor, rtk2, and an adhesion protein, DM-GRASP, mark early asymmetries in visceral endoderm [2].
  • The initial expression of zebrafish fli-1 in the posterior lateral mesoderm overlaps with that of gata2 in a potential haemangioblast population which likely contains precursors of blood and endothelium [3].

References

  1. In vivo imaging of embryonic vascular development using transgenic zebrafish. Lawson, N.D., Weinstein, B.M. Dev. Biol. (2002) [Pubmed]
  2. Regulation of left-right asymmetries in the zebrafish by Shh and BMP4. Schilling, T.F., Concordet, J.P., Ingham, P.W. Dev. Biol. (1999) [Pubmed]
  3. Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Brown, L.A., Rodaway, A.R., Schilling, T.F., Jowett, T., Ingham, P.W., Patient, R.K., Sharrocks, A.D. Mech. Dev. (2000) [Pubmed]
 
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