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Gene Review

Fli1  -  Friend leukemia integration 1

Mus musculus

Synonyms: EWSR2, Fli-1, Friend leukemia integration 1 transcription factor, Retroviral integration site protein Fli-1, SIC-1, ...
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Disease relevance of Fli1


High impact information on Fli1


Biological context of Fli1


Anatomical context of Fli1


Associations of Fli1 with chemical compounds


Physical interactions of Fli1

  • We also identified that Fli-1 DNA binding increased in G-CSF-treated cells compared with untreated cells [12].
  • In previous studies we demonstrated that Tel binds to Fli-1 and blocks transactivation of megakaryocytic promoters by Fli-1 [13].

Regulatory relationships of Fli1


Other interactions of Fli1

  • Finally, we showed that the half-life of Fli-1 is prolonged in G-CSF-treated cells compared with control-treated cells [12].
  • Subsequent molecular analysis demonstrated that both the -8 enhancer and the promoter depend on conserved Ets sites, which were bound in endothelial cells in vivo by Fli-1, Erg, and Elf-1 [15].
  • Fli-1(+/-) MRL/lpr mice had significantly decreased serum levels of total IgG and anti-dsDNA Abs as disease progressed [16].
  • Retroviral insertional activation of Fli-1 is the first detectable genetic alteration associated with F-MuLV-induced primary erythroleukemias, while mutations within p53 are only observed in Epo-dependent (ED) cell lines derived from syngeneic mice serially transplanted with F-MuLV-induced primary erythroleukemias [17].
  • A human Fli-1-derived genomic fragment containing the GATA/EBS led to enhanced transcription when positioned upstream of the SV40 promoter in the erythroleukemic HEL cell line [18].

Analytical, diagnostic and therapeutic context of Fli1


  1. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Spyropoulos, D.D., Pharr, P.N., Lavenburg, K.R., Jackers, P., Papas, T.S., Ogawa, M., Watson, D.K. Mol. Cell. Biol. (2000) [Pubmed]
  2. Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas. Bergeron, D., Poliquin, L., Kozak, C.A., Rassart, E. J. Virol. (1991) [Pubmed]
  3. Importance of Receptor Usage, Fli1 Activation, and Mouse Strain for the Stem Cell Specificity of 10A1 Murine Leukemia Virus Leukemogenicity. Rodenburg, M., Fischer, M., Engelmann, A., Harbers, S.O., Ziegler, M., L??hler, J., Stocking, C. J. Virol. (2007) [Pubmed]
  4. Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1. Ben-David, Y., Giddens, E.B., Letwin, K., Bernstein, A. Genes Dev. (1991) [Pubmed]
  5. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Hart, A., Melet, F., Grossfeld, P., Chien, K., Jones, C., Tunnacliffe, A., Favier, R., Bernstein, A. Immunity (2000) [Pubmed]
  6. Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus. Ben-David, Y., Giddens, E.B., Bernstein, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains. Kim, M.G., Chen, C., Lyu, M.S., Cho, E.G., Park, D., Kozak, C., Schwartz, R.H. Immunogenetics (1999) [Pubmed]
  8. Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice. Masuya, M., Moussa, O., Abe, T., Deguchi, T., Higuchi, T., Ebihara, Y., Spyropoulos, D.D., Watson, D.K., Ogawa, M. Blood (2005) [Pubmed]
  9. Cloning and expression of the murine Elf-1 cDNA. Davis, J.N., Roussel, M.F. Gene (1996) [Pubmed]
  10. The Ets family contains transcriptional activators and repressors involved in angiogenesis. Lelièvre, E., Lionneton, F., Soncin, F., Vandenbunder, B. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  11. Spi-1/PU.1 is a positive regulator of the Fli-1 gene involved in inhibition of erythroid differentiation in friend erythroleukemic cell lines. Starck, J., Doubeikovski, A., Sarrazin, S., Gonnet, C., Rao, G., Skoultchi, A., Godet, J., Dusanter-Fourt, I., Morle, F. Mol. Cell. Biol. (1999) [Pubmed]
  12. G-CSF induces stabilization of ETS protein Fli-1 during myeloid cell development. Mora-Garcia, P., Wei, J., Sakamoto, K.M. Pediatr. Res. (2005) [Pubmed]
  13. The ETS family member Tel antagonizes the Fli-1 phenotype in hematopoietic cells. Kwiatkowski, B.A., Zielinska-Kwiatkowska, A.G., Bauer, T.R., Hickstein, D.D. Blood Cells Mol. Dis. (2000) [Pubmed]
  14. Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia. Mélet, F., Motro, B., Rossi, D.J., Zhang, L., Bernstein, A. Mol. Cell. Biol. (1996) [Pubmed]
  15. Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer. Pimanda, J.E., Chan, W.Y., Donaldson, I.J., Bowen, M., Green, A.R., Göttgens, B. Blood (2006) [Pubmed]
  16. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. Zhang, X.K., Gallant, S., Molano, I., Moussa, O.M., Ruiz, P., Spyropoulos, D.D., Watson, D.K., Gilkeson, G. J. Immunol. (2004) [Pubmed]
  17. Activation of the erythropoietin gene in the majority of F-MuLV-induced erythroleukemias results in growth factor independence and enhanced tumorigenicity. Howard, J.C., Berger, L., Bani, M.R., Hawley, R.G., Ben-David, Y. Oncogene (1996) [Pubmed]
  18. The GATA-1 and Spi-1 transcriptional factors bind to a GATA/EBS dual element in the Fli-1 exon 1. Barbeau, B., Barat, C., Bergeron, D., Rassart, E. Oncogene (1999) [Pubmed]
  19. Analysis of proviruses integrated in Fli-1 and Evi-1 regions in Cas-Br-E MuLV-induced non-T-, non-B-cell leukemias. Bergeron, D., Poliquin, L., Houde, J., Barbeau, B., Rassart, E. Virology (1992) [Pubmed]
  20. Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in Ewing sarcoma. Toub, N., Bertrand, J.R., Tamaddon, A., Elhamess, H., Hillaireau, H., Maksimenko, A., Maccario, J., Malvy, C., Fattal, E., Couvreur, P. Pharm. Res. (2006) [Pubmed]
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