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Gene Review

egr2b  -  early growth response 2b

Danio rerio

Synonyms: EGR-2b, Early growth response protein 2b, KRX-20, Protein krx-20, SO:0000704, ...
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High impact information on egr2b

  • First, vhnf1 promotes r5+r6 identity through an obligate synergy with Fgf signals to activate valentino and krox20 expression [1].
  • Widespread overexpression of Pou2 can rescue the segmental krx20 and val domains in spg mutants, but does not induce ectopic expression of these genes [2].
  • The latter being established through differential expression of a hierarchy of transcription factors, including Hox genes, Krox20, and Kreisler/Valentino [3].
  • Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development [4].
  • To begin to examine the function of genes that control early development in the hindbrain, we have screened an embryonic zebrafish cDNA library with a murine krox-20 gene probe that contained the conserved zinc finger regions [4].

Biological context of egr2b


Anatomical context of egr2b

  • Furthermore, in the absence of functional rbmx, expression of specific markers for the fore- and hindbrain (otx2, krox20) was severely reduced [8].

Other interactions of egr2b

  • The identity of each rhombomere is specified by the expression of conserved transcription factors, including Krox-20, vHnf1, Val (Kreisler, Mafb) and several Hox proteins [9].
  • Double in situ hybridization with krox20 and cyp26d1 reveals that cyp26d1 is expressed in presumptive rhombomere 2-4 (r2-r4) at 2-somite stage [10].
  • Our results indicate that reduction in Brg1 expression leads to the expansion of the forebrain-specific transcription factor, six3, and marked reduction in expression of the mid/hind-brain boundary and hind-brain genes, engrailed2 and krox20, respectively [11].


  1. vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain. Wiellette, E.L., Sive, H. Development (2003) [Pubmed]
  2. spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Hauptmann, G., Belting, H.G., Wolke, U., Lunde, K., Söll, I., Abdelilah-Seyfried, S., Prince, V., Driever, W. Development (2002) [Pubmed]
  3. Establishment of hindbrain segmental identity requires signaling by FGF3 and FGF8. Walshe, J., Maroon, H., McGonnell, I.M., Dickson, C., Mason, I. Curr. Biol. (2002) [Pubmed]
  4. Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development. Oxtoby, E., Jowett, T. Nucleic Acids Res. (1993) [Pubmed]
  5. Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse. Grose, R., Harris, B.S., Cooper, L., Topilko, P., Martin, P. Dev. Dyn. (2002) [Pubmed]
  6. Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injection: disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos. Yan, Y.L., Jowett, T., Postlethwait, J.H. Dev. Dyn. (1998) [Pubmed]
  7. A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish. Sun, Z., Shi, K., Su, Y., Meng, A. Mech. Dev. (2002) [Pubmed]
  8. RBMX gene is essential for brain development in zebrafish. Tsend-Ayush, E., O'Sullivan, L.A., Grützner, F.S., Onnebo, S.M., Lewis, R.S., Delbridge, M.L., Marshall Graves, J.A., Ward, A.C. Dev. Dyn. (2005) [Pubmed]
  9. Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Maves, L., Kimmel, C.B. Dev. Biol. (2005) [Pubmed]
  10. Molecular cloning and expression of a novel CYP26 gene (cyp26d1) during zebrafish early development. Gu, X., Xu, F., Wang, X., Gao, X., Zhao, Q. Gene Expr. Patterns (2005) [Pubmed]
  11. Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish. Eroglu, B., Wang, G., Tu, N., Sun, X., Mivechi, N.F. Dev. Dyn. (2006) [Pubmed]
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