High impact information on Zfp354c

• The AJ18 gene consists of at least four exons, the first exon coding for an unusually long 2.3 kb 5'-UTR region [1].
• To study the regulation of expression of the AJ18 gene, the 5'-flanking region of the AJ18 gene was obtained by screening a rat genomic library [1].
• AJ18 was shown to bind to the osteoblast-specific element2 (OSE2) and to modulate transactivation by Runx2, a master gene in osteoblastic differentiation [2].
• Therefore, the expression of AJ18 is consistent with its perceived role as a transcriptional factor that regulates developmental processes downstream of BMP-7 [2].
• Temporal and spatial expression of a novel zinc finger transcription factor, AJ18, in developing murine skeletal tissues [2].

Biological context of Zfp354c

• AJ18 mRNA expression was observed in most tissues, except liver, and was generally highest early in embryonic development, decreasing markedly after parturition [2].

Anatomical context of Zfp354c

• In addition, in 4-week-old mice staining of AJ18 was observed within alveolar bone cells and periodontal ligament cells [2].
• In endochondral bones of embryonic and 4-week-old mice, immunostaining for AJ18 was strong in the nuclei of proliferating and pre-hypertrophic chondrocytes, and osteoblasts, whereas there was low or no staining in hypertrophic chondrocytes [2].

Other interactions of Zfp354c

• Using differential display we previously identified AJ18, a zinc finger transcription factor, as an immediate-early response gene to BMP-7 [2].
• Here we report the characterisation of Kid3, a novel mouse gene related to Kid1 [3].

References