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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Zfp354a  -  zinc finger protein 354A

Mus musculus

Synonyms: AW488485, Kid1, Kidney, ischemia, and developmentally-regulated protein 1, Renal transcription factor Kid-1, TCF-17, ...
 
 
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Disease relevance of Zfp354a

  • In the case of kallikrein 6, mouse deoxyribonuclease I and Kid1, which are also difficult to express in E. coli, the expression level of each protein increased when proteins were expressed at low temperature (4 degrees C) [1].
 

High impact information on Zfp354a

  • The tetracycline-controlled transcriptional silencer (tTS), a fusion protein containing the tet repressor and the KRAB-AB domain of the kid-1 transcriptional repressor, is inhibited by doxycycline [2].
  • Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2 [3].
  • Kid1 encodes a zinc finger protein that has been implicated in renal cell differentiation [3].
  • Levels of Kid1 mRNA correlate with maturation of kidney tubule epithelia in rat post-natal kidney development and during kidney regeneration following injury [3].
  • Here we report the characterisation of Kid3, a novel mouse gene related to Kid1 [4].
 

Biological context of Zfp354a

 

Anatomical context of Zfp354a

References

  1. A novel system for expressing recombinant proteins over a wide temperature range from 4 to 35 degrees C. Nakashima, N., Tamura, T. Biotechnol. Bioeng. (2004) [Pubmed]
  2. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. Zhu, Z., Ma, B., Homer, R.J., Zheng, T., Elias, J.A. J. Biol. Chem. (2001) [Pubmed]
  3. Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2. Tekki-Kessaris, N., Bonventre, J.V., Boulter, C.A. Gene (1999) [Pubmed]
  4. Characterisation, chromosomal localisation and expression of the mouse Kid3 gene. Watson, R.P., Tekki-Kessaris, N., Boulter, C.A. Biochim. Biophys. Acta (2000) [Pubmed]
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