The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DNAJC6  -  DnaJ (Hsp40) homolog, subfamily C, member 6

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on DNAJC6


Biological context of DNAJC6


Anatomical context of DNAJC6


Associations of DNAJC6 with chemical compounds

  • A detailed sequence comparison indicates that the PTP-like domain in tensin is unlikely to exhibit phosphatase activity, whereas in auxilin it may possess a different phosphatase specificity from tyrosine phosphatases [7].

Regulatory relationships of DNAJC6

  • Auxilin also induced polymerization of Hsc70 and bound to the resulting polymer at a 1:1 molar ratio; here too the dissociation constant was 0.6 microM [8].

Other interactions of DNAJC6

  • The Hsc70 molecular chaperone effects the uncoating reaction, and is guided to appropriate locations on clathrin lattices by the J-domain-containing co-chaperone molecule auxilin [9].

Analytical, diagnostic and therapeutic context of DNAJC6

  • Recombinant auxilin expressed in and purified from bacteria by affinity chromatography is functional with respect to clathrin binding [5].
  • Here, we have used electron cryomicroscopy to determine 12-A-resolution structures of in-vitro-assembled clathrin coats in association with a carboxy-terminal fragment of auxilin that contains both the clathrin-binding region and the J domain [9].
  • Immunoblotting did not reveal the presence of auxilin in tissues other than brain [4].
  • We find that during coat assembly small and variable amounts of auxilin are recruited transiently but that a much larger burst of association occurs after the peak of dynamin signal, during the transition between membrane constriction and vesicle budding [10].


  1. Role of auxilin in uncoating clathrin-coated vesicles. Ungewickell, E., Ungewickell, H., Holstein, S.E., Lindner, R., Prasad, K., Barouch, W., Martin, B., Greene, L.E., Eisenberg, E. Nature (1995) [Pubmed]
  2. Uncoating of clathrin-coated vesicles in presynaptic terminals: roles for Hsc70 and auxilin. Morgan, J.R., Prasad, K., Jin, S., Augustine, G.J., Lafer, E.M. Neuron (2001) [Pubmed]
  3. Mechanism of clathrin basket dissociation: separate functions of protein domains of the DnaJ homologue auxilin. Holstein, S.E., Ungewickell, H., Ungewickell, E. J. Cell Biol. (1996) [Pubmed]
  4. Auxilin, a newly identified clathrin-associated protein in coated vesicles from bovine brain. Ahle, S., Ungewickell, E. J. Cell Biol. (1990) [Pubmed]
  5. Primary structure of the neuronal clathrin-associated protein auxilin and its expression in bacteria. Schröder, S., Morris, S.A., Knorr, R., Plessmann, U., Weber, K., Nguyen, G.V., Ungewickell, E. Eur. J. Biochem. (1995) [Pubmed]
  6. Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface. Jiang, J., Taylor, A.B., Prasad, K., Ishikawa-Brush, Y., Hart, P.J., Lafer, E.M., Sousa, R. Biochemistry (2003) [Pubmed]
  7. The N-terminal domains of tensin and auxilin are phosphatase homologues. Haynie, D.T., Ponting, C.P. Protein Sci. (1996) [Pubmed]
  8. Interaction of auxilin with the molecular chaperone, Hsc70. Jiang, R.F., Greener, T., Barouch, W., Greene, L., Eisenberg, E. J. Biol. Chem. (1997) [Pubmed]
  9. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Fotin, A., Cheng, Y., Grigorieff, N., Walz, T., Harrison, S.C., Kirchhausen, T. Nature (2004) [Pubmed]
  10. A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Massol, R.H., Boll, W., Griffin, A.M., Kirchhausen, T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
WikiGenes - Universities