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Gene Review

DNM1  -  dynamin 1

Homo sapiens

Synonyms: DNM, Dynamin-1
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Disease relevance of DNM1

  • Moreover, we show that internalization of PA is dynamin and Eps15 dependent, indicating that the clathrin-dependent pathway is the major route of anthrax toxin entry into the cell [1].
  • Based on the FAP-1- and dynamin-dependent regulation of Fas translocation, we have created human melanoma lines with different levels of surface expression of Fas [2].
  • Finally, dynamin is apparently not involved in the formation of phagocytic vesicles containing Chlamydia [3].
  • Inducible expression of a dominant-negative mutant of dynamin in a CD4-positive HeLa cell line reduced HIV infection by 40 to 80% [4].
  • Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells [5].

Psychiatry related information on DNM1

  • In cortical neurons of Huntington's disease patients with early stage pathology, dynamin immunoreactivity accumulated in cytoplasmic bodies [6].
  • Overexpression of dynamin is induced by chronic stimulation of mu- but not delta-opioid receptors: relationships with mu-related morphine dependence [7].
  • The results show a similar down-regulation and desensitization of mu and delta binding sites, whereas an overexpression of dynamin occurred only with mu agonists, strongly suggesting the relevance of this up-regulation with the opiate dependence [7].
  • Subjects were 33 abstinent SDIs receiving inpatient treatment and 19 non-SDI normal controls (NC) well-matched on age, sex, ethnicity, and VIQ, who were assessed using the Iowa Gambling Task (GT) and a delayed non-match to sample task (DNM): measures of decision making and working memory, respectively [8].

High impact information on DNM1


Chemical compound and disease context of DNM1


Biological context of DNM1


Anatomical context of DNM1


Associations of DNM1 with chemical compounds

  • Although dynamin localization to the tails required its proline-rich domain, expression of a dynamin mutant lacking this domain also diminished tail formation [23].
  • Dynamin GTPase activity is essential for its fission activity, and it is stimulated by self-assembly as well as by interacting with its binding partners, such as microtubules, SH3 domain containing proteins, or inositol phospholipids [25].
  • We describe here in detail the procedure of the dynamin GTPase assay and the results demonstrating stimulatory effect of amphiphysin on dynamin GTPase activity, which is highly dependent on the liposome size [25].
  • Nitric oxide regulates endocytosis by S-nitrosylation of dynamin [26].
  • We report that dynamin, which interacts with NO synthase, is S-nitrosylated at a single cysteine residue (C607) after stimulation of the beta(2) adrenergic receptor [26].

Physical interactions of DNM1


Co-localisations of DNM1

  • LPS was endocytosed by a receptor-mediated mechanism dependent on dynamin and clathrin and colocalized with TLR4 on early/sorting endosomes [32].

Regulatory relationships of DNM1


Other interactions of DNM1

  • Amphiphysin I and II are nerve terminal-enriched proteins that display src homology 3 domain-mediated interactions with dynamin and synaptojanin [24].
  • Hudy-2 binds to an epitope within amino acids 822-838 that is common to dynamin-1 and dynamin-2 [33].
  • Dynamin associates with a variety of SH3 domain-containing molecules via a C-terminal proline-rich motif and takes part, with them, in endocytic processes [37].
  • These findings suggest that PLD, functioning as an intermolecular GAP for dynamin, accelerates EGFR endocytosis [38].
  • First, we show that L. monocytogenes colocalizes with Met, EEA1, Cbl, clathrin and dynamin during entry [39].

Analytical, diagnostic and therapeutic context of DNM1


  1. Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. Abrami, L., Liu, S., Cosson, P., Leppla, S.H., van der Goot, F.G. J. Cell Biol. (2003) [Pubmed]
  2. Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis. Ivanov, V.N., Ronai, Z., Hei, T.K. J. Biol. Chem. (2006) [Pubmed]
  3. Chlamydia infection of epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth. Boleti, H., Benmerah, A., Ojcius, D.M., Cerf-Bensussan, N., Dautry-Varsat, A. J. Cell. Sci. (1999) [Pubmed]
  4. Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry. Daecke, J., Fackler, O.T., Dittmar, M.T., Kräusslich, H.G. J. Virol. (2005) [Pubmed]
  5. Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells. Yoon, S.Y., Jeong, M.J., Yoo, J., Lee, K.I., Kwon, B.M., Lim, D.S., Lee, C.E., Park, Y.M., Han, M.Y. J. Cell. Biochem. (2001) [Pubmed]
  6. Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. Qin, Z.H., Wang, Y., Sapp, E., Cuiffo, B., Wanker, E., Hayden, M.R., Kegel, K.B., Aronin, N., DiFiglia, M. J. Neurosci. (2004) [Pubmed]
  7. Overexpression of dynamin is induced by chronic stimulation of mu- but not delta-opioid receptors: relationships with mu-related morphine dependence. Noble, F., Szücs, M., Kieffer, B., Roques, B.P. Mol. Pharmacol. (2000) [Pubmed]
  8. Executive functions among individuals with methamphetamine or alcohol as drugs of choice: preliminary observations. Gonzalez, R., Bechara, A., Martin, E.M. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society (2007) [Pubmed]
  9. Cargo regulates clathrin-coated pit dynamics. Puthenveedu, M.A., von Zastrow, M. Cell (2006) [Pubmed]
  10. TTP specifically regulates the internalization of the transferrin receptor. Tosoni, D., Puri, C., Confalonieri, S., Salcini, A.E., De Camilli, P., Tacchetti, C., Di Fiore, P.P. Cell (2005) [Pubmed]
  11. SNARE filtering by dynamin. Antonny, B. Cell (2004) [Pubmed]
  12. Dynamin undergoes a GTP-dependent conformational change causing vesiculation. Sweitzer, S.M., Hinshaw, J.E. Cell (1998) [Pubmed]
  13. Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin. Ferguson, K.M., Lemmon, M.A., Schlessinger, J., Sigler, P.B. Cell (1994) [Pubmed]
  14. Differential internalization of mammalian and non-mammalian gonadotropin-releasing hormone receptors. Uncoupling of dynamin-dependent internalization from mitogen-activated protein kinase signaling. Hislop, J.N., Everest, H.M., Flynn, A., Harding, T., Uney, J.B., Troskie, B.E., Millar, R.P., McArdle, C.A. J. Biol. Chem. (2001) [Pubmed]
  15. Ebola virus glycoprotein toxicity is mediated by a dynamin-dependent protein-trafficking pathway. Sullivan, N.J., Peterson, M., Yang, Z.Y., Kong, W.P., Duckers, H., Nabel, E., Nabel, G.J. J. Virol. (2005) [Pubmed]
  16. Molecular structures of 2,4-diaminopyrimidine antifolates with antineoplastic activity. Cody, V., Zakrzewski, S.F. J. Med. Chem. (1982) [Pubmed]
  17. Relationship between Daunorubicin dosage delivered during induction therapy and outcome in adult acute lymphoblastic leukemia. Todeschini, G., Meneghini, V., Pizzolo, G., Cassibba, V., Ambrosetti, A., Veneri, D., Nadali, G., Zanotti, R., Tecchio, C., Perona, G. Leukemia (1994) [Pubmed]
  18. Cortactin and dynamin are required for the clathrin-independent endocytosis of gammac cytokine receptor. Sauvonnet, N., Dujeancourt, A., Dautry-Varsat, A. J. Cell Biol. (2005) [Pubmed]
  19. Endophilin-1: a multifunctional protein. Reutens, A.T., Begley, C.G. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  20. Dynamin and endocytosis. Sever, S. Curr. Opin. Cell Biol. (2002) [Pubmed]
  21. Differential regulation of interleukin 5-stimulated signaling pathways by dynamin. Gorska, M.M., Cen, O., Liang, Q., Stafford, S.J., Alam, R. J. Biol. Chem. (2006) [Pubmed]
  22. Dynamin GTPase domain mutants that differentially affect GTP binding, GTP hydrolysis, and clathrin-mediated endocytosis. Song, B.D., Leonard, M., Schmid, S.L. J. Biol. Chem. (2004) [Pubmed]
  23. Dynamin at actin tails. Lee, E., De Camilli, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  24. Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites. Ramjaun, A.R., McPherson, P.S. J. Neurochem. (1998) [Pubmed]
  25. Stimulation of dynamin GTPase activity by amphiphysin. Yoshida, Y., Takei, K. Meth. Enzymol. (2005) [Pubmed]
  26. Nitric oxide regulates endocytosis by S-nitrosylation of dynamin. Wang, G., Moniri, N.H., Ozawa, K., Stamler, J.S., Daaka, Y. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  27. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Soulet, F., Yarar, D., Leonard, M., Schmid, S.L. Mol. Biol. Cell (2005) [Pubmed]
  28. The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis. Veugelers, K., Motyka, B., Frantz, C., Shostak, I., Sawchuk, T., Bleackley, R.C. Blood (2004) [Pubmed]
  29. The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. Grabs, D., Slepnev, V.I., Songyang, Z., David, C., Lynch, M., Cantley, L.C., De Camilli, P. J. Biol. Chem. (1997) [Pubmed]
  30. Dynamin interacts with members of the sumoylation machinery. Mishra, R.K., Jatiani, S.S., Kumar, A., Simhadri, V.R., Hosur, R.V., Mittal, R. J. Biol. Chem. (2004) [Pubmed]
  31. Dynamin: characteristics, mechanism of action and function. Wiejak, J., Wyroba, E. Cell. Mol. Biol. Lett. (2002) [Pubmed]
  32. Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. Husebye, H., Halaas, Ø., Stenmark, H., Tunheim, G., Sandanger, Ø., Bogen, B., Brech, A., Latz, E., Espevik, T. EMBO J. (2006) [Pubmed]
  33. Dynamin GTPase is stimulated by crosslinking through the C-terminal proline-rich domain. Warnock, D.E., Terlecky, L.J., Schmid, S.L. EMBO J. (1995) [Pubmed]
  34. Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. Ahn, S., Maudsley, S., Luttrell, L.M., Lefkowitz, R.J., Daaka, Y. J. Biol. Chem. (1999) [Pubmed]
  35. Internalization and desensitization of the oxytocin receptor is inhibited by Dynamin and clathrin mutants in human embryonic kidney 293 cells. Smith, M.P., Ayad, V.J., Mundell, S.J., McArdle, C.A., Kelly, E., López Bernal, A. Mol. Endocrinol. (2006) [Pubmed]
  36. Profilin I attached to the Golgi is required for the formation of constitutive transport vesicles at the trans-Golgi network. Dong, J., Radau, B., Otto, A., Müller, E., Lindschau, C., Westermann, P. Biochim. Biophys. Acta (2000) [Pubmed]
  37. A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. Kamioka, Y., Fukuhara, S., Sawa, H., Nagashima, K., Masuda, M., Matsuda, M., Mochizuki, N. J. Biol. Chem. (2004) [Pubmed]
  38. The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis. Lee, C.S., Kim, I.S., Park, J.B., Lee, M.N., Lee, H.Y., Suh, P.G., Ryu, S.H. Nat. Cell Biol. (2006) [Pubmed]
  39. Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells. Veiga, E., Cossart, P. Nat. Cell Biol. (2005) [Pubmed]
  40. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? Okamoto, M., Schoch, S., Südhof, T.C. J. Biol. Chem. (1999) [Pubmed]
  41. Dynamin associates with Src-Homology Collagen (Shc) and becomes tyrosine phosphorylated in response to insulin. Baron, V., Alengrin, F., Van Obberghen, E. Endocrinology (1998) [Pubmed]
  42. Production and characterization of monoclonal antibodies against amphiphysins. Jin, Y., Kim, K.Y., Soung, N.K., Shin, E.Y., Kim, E.G., Kim, S.R. Exp. Mol. Med. (2001) [Pubmed]
  43. Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions. Shupliakov, O., Löw, P., Grabs, D., Gad, H., Chen, H., David, C., Takei, K., De Camilli, P., Brodin, L. Science (1997) [Pubmed]
  44. Endocytic vesicle scission by lipid phase boundary forces. Liu, J., Kaksonen, M., Drubin, D.G., Oster, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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