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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

AP-1gamma  -  Adaptor Protein complex 1, gamma subunit

Drosophila melanogaster

Synonyms: AP-1, AP-1 gamma, AP-1[gamma], AP1gamma, AP1gamma1, ...
 
 
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High impact information on AP-1gamma

  • Proteins that acted through a cooperative interaction between an AP-1 and an unrecognized cAMP response element (CRE)-like site were also identified [1].
  • The DNA-binding domain is more closely related to mammalian CREB than to the AP-1 factors in both sequence homology and specificity of cAMP-responsive element binding [2].
  • Additionally we have identified a potential cAMP response element, AP-1 and E box sites, and two elements demonstrated in other genes to confer placenta-specific expression [3].
  • Our studies indicate that the Drosophila ras2 promoter region shares with the human c-Ha-ras1 promoter a CACCC box and an AP-1-like sequence [4].
  • The presence of overlapping AP-1 and antioxidant responsive-like sequences that appear functional in transfected vertebrate cells suggest that the recruitment of glutathione S-transferase to S-crystallins involved response to oxidative stress [5].
 

Biological context of AP-1gamma

  • These cytosolic effectors in turn lead to altered programs of gene expression by activating, among others, AP-1 and serum response factor transcription factors [6].

References

  1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J.M., Orth, A.P., Miraglia, L., Meltzer, J., Garza, D., Chirn, G.W., McWhinnie, E., Cohen, D., Skelton, J., Terry, R., Yu, Y., Bodian, D., Buxton, F.P., Zhu, J., Song, C., Labow, M.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper family. Smolik, S.M., Rose, R.E., Goodman, R.H. Mol. Cell. Biol. (1992) [Pubmed]
  3. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. Schmidt, J.V., Carver, L.A., Bradfield, C.A. J. Biol. Chem. (1993) [Pubmed]
  4. Conserved cis-elements bind a protein complex that regulates Drosophila ras2/rop bidirectional expression. Lightfoot, K., Maltby, L., Duarte, R., Veale, R., Segev, O. Br. J. Cancer (1994) [Pubmed]
  5. Lens crystallins of invertebrates--diversity and recruitment from detoxification enzymes and novel proteins. Tomarev, S.I., Piatigorsky, J. Eur. J. Biochem. (1996) [Pubmed]
  6. Endothelin peptides and compensatory growth of renal cells. Simonson, M.S. Curr. Opin. Nephrol. Hypertens. (1994) [Pubmed]
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