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Gene Review

Ap1g1  -  adaptor protein complex AP-1, gamma 1 subunit

Mus musculus

Synonyms: AA409002, AP-1 complex subunit gamma-1, AU041323, AW551707, Adaptor protein complex AP-1 subunit gamma-1, ...
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High impact information on Ap1g1

  • Polarized epithelial cells are the only cells of micro1A-adaptin-deficient embryos that show gamma-adaptin binding to membranes, indicating the formation of an epithelial specific AP-1B complex and demonstrating the absence of additional mu1A homologs [1].
  • Using a polyclonal antibody against the mouse gamma-adaptin, we have now examined the steady state distribution of AP-1 after subcellular fractionation of mouse fibroblasts lacking both MPRs or reexpressing physiological levels of either MPR [2].
  • The deduced amino acid sequence of gamma-adaptin was found to be homologous to that of alpha-adaptin, with several stretches of identical amino acids or conservative substitutions in the first approximately 70 kD, and 25% identity overall [3].
  • Like both alpha- and beta-adaptins, gamma-adaptin has a proline and glycine-rich hinge region, dividing it into NH2- and COOH-terminal domains [3].
  • Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus [3].

Biological context of Ap1g1

  • We generated mutants of the gamma-adaptin subunit of AP-1 in mice to investigate its role in post-Golgi vesicle transport and sorting processes. gamma-Adaptin-deficient embryos develop until day 3.5 post coitus and die during the prenidation period, revealing that AP-1 is essential for viability [4].
  • The GGAs (Golgi-localizing, gamma-adaptin ear homology domain, ARF-binding) are a multidomain family of proteins implicated in protein trafficking between the Golgi and endosomes [5].

Anatomical context of Ap1g1


Associations of Ap1g1 with chemical compounds


  1. mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. Meyer, C., Zizioli, D., Lausmann, S., Eskelinen, E.L., Hamann, J., Saftig, P., von Figura, K., Schu, P. EMBO J. (2000) [Pubmed]
  2. Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN. Le Borgne, R., Hoflack, B. J. Cell Biol. (1997) [Pubmed]
  3. Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus. Robinson, M.S. J. Cell Biol. (1990) [Pubmed]
  4. Early embryonic death of mice deficient in gamma-adaptin. Zizioli, D., Meyer, C., Guhde, G., Saftig, P., von Figura, K., Schu, P. J. Biol. Chem. (1999) [Pubmed]
  5. Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. Doray, B., Bruns, K., Ghosh, P., Kornfeld, S. J. Biol. Chem. (2002) [Pubmed]
  6. Differential expression of lysosomal associated membrane protein (LAMP-1) during mammalian spermiogenesis. Moreno, R.D. Mol. Reprod. Dev. (2003) [Pubmed]
  7. A novel AP180-related protein in vesicles that concentrate at acetylcholine receptor clusters. Bursztajn, S., Vincent, S., Brodsky, F.M., Benes, F., Morris, S.A. J. Cell. Biochem. (1998) [Pubmed]
  8. Mutational analysis of the carboxy-terminal phosphorylation site of GLUT-4 in 3T3-L1 adipocytes. Marsh, B.J., Martin, S., Melvin, D.R., Martin, L.B., Alm, R.A., Gould, G.W., James, D.E. Am. J. Physiol. (1998) [Pubmed]
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