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Gene Review

EDN2  -  endothelin 2

Bos taurus

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High impact information on EDN2

  • PURPOSE: Bovine corneal epithelial cells (BCEC) were cultured to determine whether endothelin (ET) receptor subtype stimulation affects ET isoform expression (ET-1, ET-2, and ET-3) through capacitative Ca2+ influx [1].
  • Identification of ET-1 and ET-2 gene expression in BCE strengthens the notion that this regulation could be autocrine mediated [1].
  • The incubation of big endothelin-1 (big ET-1), big ET-2 or big ET-3 with cultured bovine endothelial cells (ECs) resulted in their conversions to mature endothelins (ETs) [2].
  • These results indicate that vascular endothelium can convert exogenous big ET-1 to mature ET-1 through a phosphoramidon-sensitive metalloprotease, and that this enzyme has also high affinities for big ET-2 and big ET-3 [2].


  1. Endothelin receptor-mediated Ca2+ signaling and isoform expression in bovine corneal epithelial cells. Tao, W., Wu, X., Liou, G.I., Abney, T.O., Reinach, P.S. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  2. Cultured bovine endothelial cells convert big endothelin isopeptides to mature endothelin isopeptides. Ohnaka, K., Takayanagi, R., Yamauchi, T., Umeda, F., Nawata, H. Biochem. Int. (1991) [Pubmed]
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