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Gene Review

EDN2  -  endothelin 2

Canis lupus familiaris

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Disease relevance of EDN2


High impact information on EDN2

  • 6. These results suggest that the vasoconstriction induced by endothelin-3 and lower doses of endothelin-1 and endothelin-2, largely depends on the influx of Ca2+ ions [2].
  • Aside from the poly (A) tail the cDNA was found to be 1195 bp and included an open reading frame of 534 bp encoding a PPET2 polypeptide of 178 residues, in which the regions corresponding to bioactive mature ET2 peptide, an intermediate form big-ET2, and endothelin-like peptide are found [3].
  • ET-2 and Ala-ET produced dose-related sustained increases in vascular resistance (10(-10) to 10(-8) M), with Ala-ET less potent than ET-2 [4].

Biological context of EDN2


Anatomical context of EDN2


Associations of EDN2 with chemical compounds


Analytical, diagnostic and therapeutic context of EDN2

  • We report here the molecular cloning of the canine full-length cDNA of the precursor form of ET2, prepro-ET2 (PPET2), from intestinal tissue by means of reverse transcription-polymerase chain reaction (RT-PCR) in conjunction with 5'- and 3'-rapid amplification of cDNA ends (RACE) [3].


  1. Response of plasma and tissue endothelin-1 to liver ischemia and its implication in ischemia-reperfusion injury. Kawamura, E., Yamanaka, N., Okamoto, E., Tomoda, F., Furukawa, K. Hepatology (1995) [Pubmed]
  2. Endothelins: vasoconstrictor effects and localization in canine cerebral arteries. Saito, A., Shiba, R., Yanagisawa, M., Masaki, T., Kimura, S., Yamada, K., Mima, T., Shigeno, T., Goto, K. Br. J. Pharmacol. (1991) [Pubmed]
  3. Cloning of full-length preproendothelin-2 cDNA and its expression in dog. Fujimori, Y., Uchide, T., Saida, K., Temma, K., Sasaki, T., Akera, T. J. Vet. Med. Sci. (2003) [Pubmed]
  4. Relative potency of endothelin analogues on changes in gastric vascular resistance. Wood, J.G., Yan, Z.Y., Cheung, L.Y. Am. J. Physiol. (1992) [Pubmed]
  5. Effects of endothelin on microcirculation of the pancreas. Takaori, K., Inoue, K., Kogire, M., Higashide, S., Tun, T., Aung, T., Doi, R., Fujii, N., Tobe, T. Life Sci. (1992) [Pubmed]
  6. Actions of endothelin-1, 2, and 3 in the microvasculature of bone. Briggs, P.J., Moran, C.G., Wood, M.B. J. Orthop. Res. (1998) [Pubmed]
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