Gene Review:
EDN2 - endothelin 2
Homo sapiens
Synonyms:
ET-2, ET2, Endothelin-2, PPET2, Preproendothelin-2
- Fifteen polymorphisms in endothelin-1, endothelin-2 and endothelin-receptor-A genotyped by four duplex assays and seven simple assays on a LightCycler using hybridization probes. Arjomand-Nahad, F., Landt, O., Stangl, K., Diefenbach, K., Roots, I. Clin. Chem. Lab. Med. (2006)
- Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Grimshaw, M.J., Wilson, J.L., Balkwill, F.R. Eur. J. Immunol. (2002)
- cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2. Bloch, K.D., Hong, C.C., Eddy, R.L., Shows, T.B., Quertermous, T. Genomics (1991)
- Endothelin-2-converting enzyme from human renal adenocarcinoma cells is a phosphoramidon-sensitive, membrane-bound metalloprotease. Shinmi, O., Yorimitsu, K., Moroi, K., Nishiyama, M., Sugita, Y., Saito, T., Inagaki, Y., Masaki, T., Kimura, S. J. Cardiovasc. Pharmacol. (1993)
- International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Davenport, A.P. Pharmacol. Rev. (2002)
- Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3. Arinami, T., Ishikawa, M., Inoue, A., Yanagisawa, M., Masaki, T., Yoshida, M.C., Hamaguchi, H. Am. J. Hum. Genet. (1991)
- A role for endothelin-2 and its receptors in breast tumor cell invasion. Grimshaw, M.J., Hagemann, T., Ayhan, A., Gillett, C.E., Binder, C., Balkwill, F.R. Cancer Res. (2004)
- Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? Spieker, L.E., Noll, G., Ruschitzka, F.T., Lüscher, T.F. J. Am. Coll. Cardiol. (2001)
- Interstitial duplication of the short arm of chromosome 1 in a newborn with congenital heart disease and multiple malformations. Warden, C.R., Pillers, D.A., Rice, M.J., Wildes, J., Livingston, J.S., Clark, B.A., Gilhooly, J.T., Magenis, R.E. Am. J. Med. Genet. (2001)
- An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration. Ong, A.C., Jowett, T.P., Firth, J.D., Burton, S., Karet, F.E., Fine, L.G. Kidney Int. (1995)
- Endothelin-2 down-regulation occurs in parallel with the anti-proliferative effect of dimethylsulfoxide in BeWO human choriocarcinoma cell line. Rebourcet, R., Mignot, T.M., Robert, B., Ferré, F. Cell. Mol. Biol. (Noisy-le-grand) (2004)
- Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis. Dimoulios, P., Kolios, G., Notas, G., Matrella, E., Xidakis, C., Koulentaki, M., Tsagarakis, N., Kouroumalis, A., Kouroumalis, E. Aliment. Pharmacol. Ther. (2005)
- Binding sites for iodinated endothelin-1, endothelin-2 and endothelin-3 demonstrated on human uterine glandular epithelial cells by quantitative high-resolution autoradiography. Davenport, A.P., Cameron, I.T., Smith, S.K., Brown, M.J. J. Endocrinol. (1991)
- Immunoreactive endothelin-1, endothelin-2 and big endothelin-1 in follicular fluids of women undergoing ovulation induction for in-vitro fertilization. Haq, A., Kayali, M., Hammami, M.M., Jaroudi, K., al-Sedairy, S.T. Hum. Reprod. (1996)
- Endothelin-A receptors mediate vasoconstriction of capillaries in the spiral ligament. Sadanaga, M., Liu, J., Wangemann, P. Hear. Res. (1997)
- Alternatively spliced mRNAs for human endothelin-2 and their tissue distribution. O'Reilly, G., Charnock-Jones, D.S., Morrison, J.J., Cameron, I.T., Davenport, A.P., Smith, S.K. Biochem. Biophys. Res. Commun. (1993)
- The mechanism of action of endothelin in human lung. McKay, K.O., Black, J.L., Armour, C.L. Br. J. Pharmacol. (1991)
- Endothelin converting enzyme (ECE) activity in human vascular smooth muscle. Maguire, J.J., Johnson, C.M., Mockridge, J.W., Davenport, A.P. Br. J. Pharmacol. (1997)
- Contraction to big endothelin-1, big endothelin-2 and big endothelin-3, and endothelin-converting enzyme inhibition in human isolated bronchi. Yap, E.Y., Battistini, B., McKay, K.O. Br. J. Pharmacol. (2000)
- Activation of phospholipase A2 and phospholipase C by endothelin-1 in human endometrium. Ahmed, A., Cameron, I.T., Ferriani, R.A., Smith, S.K. J. Endocrinol. (1992)
- Role of endothelin in diabetic vascular complications. Lam, H.C. Endocrine (2001)
- [125I]-PD151242: a selective ligand for endothelin ETA receptors in human kidney which localizes to renal vasculature. Davenport, A.P., Kuc, R.E., Hoskins, S.L., Karet, F.E., Fitzgerald, F. Br. J. Pharmacol. (1994)
- Localization of endothelin immunoreactivity and demonstration of constrictory endothelin-A receptors in human coronary arteries and veins. Saetrum Opgaard, O., Adner, M., Gulbenkian, S., Edvinsson, L. J. Cardiovasc. Pharmacol. (1994)
- Endothelin in human nasal mucosa. Mullol, J., Chowdhury, B.A., White, M.V., Ohkubo, K., Rieves, R.D., Baraniuk, J., Hausfeld, J.N., Shelhamer, J.H., Kaliner, M.A. Am. J. Respir. Cell Mol. Biol. (1993)
- Endothelin axis expression is markedly different in the two main subtypes of renal cell carcinoma. Douglas, M.L., Richardson, M.M., Nicol, D.L. Cancer (2004)
- Effect of phosphoramidon on big endothelin-2 conversion into endothelin-2 in human renal adenocarcinoma (ACHN) cells. Analysis of endothelin-2 biosynthetic pathway. Yorimitsu, K., Shinmi, O., Nishiyama, M., Moroi, K., Sugita, Y., Saito, T., Inagaki, Y., Masaki, T., Kimura, S. FEBS Lett. (1992)
- Contractile effect of endothelin-2 on the isolated human saphenous vein. Poli, E., Casoli, C., Spaggiari, I., Starcich, R., Bertaccini, G. Archives internationales de pharmacodynamie et de thérapie. (1991)
- Transgenic rats expressing the human ET-2 gene: a model for the study of endothelin actions in vivo. Liefeldt, L., Schönfelder, G., Böcker, W., Hocher, B., Talsness, C.E., Rettig, R., Paul, M. J. Mol. Med. (1999)
- Characterization of the renal phenotype of transgenic rats expressing the human endothelin-2 gene. Hocher, B., Liefeldt, L., Thöne-Reineke, C., Orzechowski, H.D., Distler, A., Bauer, C., Paul, M. Hypertension (1996)