Disease relevance of HOXB9

• At both high and low retinoic acid concentrations, HOX2 genes are sequentially activated in embryonal carcinoma cells in the 3' to 5' direction [1].

High impact information on HOXB9

• Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells [1].
• Independent variations of mRNA expression of HER-2/neu and prostate-specific antigen were observed in hormone-independent tumors whereas HOXB9 gene expression was constant [2].
• In contrast, HOXD10 and to a lesser degree HOXB9 bound the PPE with high affinities regardless of whether PBX1b was present [3].
• Our data indicate that Btg1 and Btg2 act as transcriptional cofactors of the Hoxb9 protein, and suggest that this interaction may mediate their antiproliferative function [4].
• A number of homeoboxes on chromosome 7 define the human HOX-1 locus and homeoboxes on chromosome 17 define the human HOX-2 locus [5].

Biological context of HOXB9

• Five new human HOX-2 homeoboxes, termed HOX-2.5, 2.4, 2.6, 2.7 and 2.8, have been identified, and their nucleotide sequences are reported [6].
• Analysis of skeletal features of these mice reveals the presence of a dominant phenotype consisting of homeotic transformations, similar to those observed in mice with a loss-of-function of Hox genes, such as Hoxa7, Hoxb7, and Hoxb9 [7].
• Activation of the HOX2E gene by HCMV might possibly have a role in virus-induced abnormal embryogenesis [8].

Anatomical context of HOXB9

• HOX-2.5, 2.4 and 2.3 transcripts are markedly more abundant in spinal cord than in medulla, whereas 2.2, 2.1, 2.6 and 2.7 mRNAs are progressively more abundant in the medulla [6].
• Weak expression of Hox 2.5 is detected in the spinal cord just posterior to the first cervical vertebra, and maximal expression is found posterior to the second cervical vertebra.(ABSTRACT TRUNCATED AT 400 WORDS)[9]

Associations of HOXB9 with chemical compounds

• We now show that the nine genes of the HOX2 cluster are differentially activated in NT2/D1 cells exposed to retinoic acid concentrations ranging from 10(-8) to 10(-5) M [1].
• HCMV infection markedly increased the expression of the HOX2E gene in HEL cells in the presence, but not in the absence, of cycloheximide [8].

Other interactions of HOXB9

• Our data show that ERK5 probably mediates HOXB9 expression by repressing BMI1 [10].

References