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Gene Review

Hoxb9  -  homeobox B9

Mus musculus

Synonyms: Homeobox protein Hox-2.5, Homeobox protein Hox-B9, Hox-2.5, Hoxb-9
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Disease relevance of Hoxb9


High impact information on Hoxb9

  • There is an early increase in the histone modifications that are marks of active chromatin at both the early expressed gene Hoxb1, and also at Hoxb9 that is not expressed until much later [3].
  • Hoxa9, Hoxb9, and Hoxd9 are expressed normally in adult mammary glands, suggesting a direct role for these genes in the development of mammary tissue after pregnancy [4].
  • The Mvwf candidate interval between Ngfr and Hoxb9 is approximately 0.5 centimorgan (cM) [5].
  • Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4 [1].
  • Although this construct was transcriptionally active at a low level in NIH 3T3 cells, cotransfection of CMV-Hox-2.5 resulted in CAT activity that was greatly elevated [1].

Biological context of Hoxb9


Anatomical context of Hoxb9

  • Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous genes are required for mediating the expansion and/or differentiation of the mammary epithelium ductal system in response to pregnancy [4].
  • By contrast, the overexpression of Ring1B in chick embryos results in the repression of Hoxb9 expression in the neural tube [10].
  • Three-dimensional reconstruction of Hox-2.5 transcript localization within the central nervous system of early embryos clearly illustrates the neural expression domain [11].
  • Northern and in situ hybridization analyses of Hox-2.5 demonstrate a novel, regionally restricted pattern of expression in developing mesoderm and neurectoderm [11].

Other interactions of Hoxb9

  • Thus, Hoxb13 expression seems to be independent of the deleted region, suggesting that its expression pattern could be achieved independent of the colinear pattern of the cluster or by a regulatory element located 5' of Hoxb9 [6].
  • In contrast, cotransfection with CMV-Hox-2.4 eliminated the CAT activity that was driven by the CMV-Hox-2.5 construct [1].


  1. Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4. Jones, F.S., Prediger, E.A., Bittner, D.A., De Robertis, E.M., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. The regulation of the murine Hox-2.5 gene expression during cell differentiation. Kondo, T., Takahashi, N., Muramatsu, M. Nucleic Acids Res. (1992) [Pubmed]
  3. Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription. Chambeyron, S., Bickmore, W.A. Genes Dev. (2004) [Pubmed]
  4. Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Chen, F., Capecchi, M.R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11. Mohlke, K.L., Nichols, W.C., Westrick, R.J., Novak, E.K., Cooney, K.A., Swank, R.T., Ginsburg, D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations. Medina-Martínez, O., Bradley, A., Ramírez-Solis, R. Dev. Biol. (2000) [Pubmed]
  7. Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. Wang, M., Zhang, Z., Zhang, Z., Vikis, H., Yan, Y., Wang, Y., You, M. Cancer Res. (2007) [Pubmed]
  8. A yeast artificial chromosome containing the mouse homeobox cluster Hox-2. Rubock, M.J., Larin, Z., Cook, M., Papalopulu, N., Krumlauf, R., Lehrach, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  9. The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target. Shen, W.F., Rozenfeld, S., Lawrence, H.J., Largman, C. J. Biol. Chem. (1997) [Pubmed]
  10. Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Suzuki, M., Mizutani-Koseki, Y., Fujimura, Y., Miyagishima, H., Kaneko, T., Takada, Y., Akasaka, T., Tanzawa, H., Takihara, Y., Nakano, M., Masumoto, H., Vidal, M., Isono, K., Koseki, H. Development (2002) [Pubmed]
  11. The developmental expression pattern of a new murine homeo box gene: Hox-2.5. Bogarad, L.D., Utset, M.F., Awgulewitsch, A., Miki, T., Hart, C.P., Ruddle, F.H. Dev. Biol. (1989) [Pubmed]
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