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Gene Review

HDAC11  -  histone deacetylase 11

Homo sapiens

Synonyms: HD11, Histone deacetylase 11
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Disease relevance of HDAC11

  • We have demonstrated expression of proinflammatory cytokines and chemokines in response to Campylobacter infection in avian primary chick kidney cells and the avian macrophage cell line HD11 [1].
  • PURPOSE: To guarantee the treatment quality of involved-field radiotherapy (IF-RT) of patients in the Hodgkin's disease (HD)10 and HD11 trials of the German Hodgkin Study Group, with 460 participating study centers, a quality assurance program was conducted [2].
  • The HD11 antibody at a concentration of 1 microgram/ml completely protected against the T-2-induced cytotoxicity of the human epidermoid carcinoma cell lines Hep-2 and KB [3].
  • Intracellular killing of Salmonella enteritidis (SE) was also increased in ODN 2006-activated HD11 cells [4].

High impact information on HDAC11


Chemical compound and disease context of HDAC11


Biological context of HDAC11


Anatomical context of HDAC11

  • We have isolated a novel 75-kDa gelatinase from a chicken macrophage cell line, HD11 [9].
  • On a per cell basis, the activity of HD-11 cell 25-OHD3 1-hydroxylation reaction was comparable to that in primary cultures of chick renal tubular epithelial cells, which express the authentic renal 25-OHD3 1-hydroxylase [10].
  • In these experiments we employed inducible nitric oxide synthase (iNOS)-free, intact mitochondria preparations from the avain macrophage-like cell line HD-11, which constitutively express the 1-hydroxylase, and nonenzymatically-generated NO to investigate NO-mediated autoregulation of the macrophage 1-hydroxylase [11].
  • This study demonstrates the effects of recombinant human tumour necrosis factor a (rhTNF-alpha) and conditioned medium of the HD11-transformed chicken macrophage cell line on cultured chicken granulosa cells [12].
  • Upon induction with lipopolysaccharide (LPS) the chicken macrophage cell line HD-11 secretes an activity that stimulates the synthesis of a CXC chemokine in the chicken fibroblast cell line CEC-32 [13].

Associations of HDAC11 with chemical compounds


Other interactions of HDAC11

  • We have cloned and characterized a human cDNA that belongs to the histone deacetylase family, which we designate as HDAC11 [5].
  • We have analysed whether WNT7A or HDAC11 was biallelically inactivated in a group of well-characterized PETs [8].
  • Randomized studies and most recently the GHSG HD 10 and HD 11 documented excellent results with low-dose IFRT of only 20 Gy in both early stage and in intermediate-stage patients [15].
  • In this study, the authors report the case of a woman with anaplastic-lymphoma-kinase (ALK)-negative CD30-positive anaplastic large cell lymphoma, whose brother had developed HD 11 years previously [16].

Analytical, diagnostic and therapeutic context of HDAC11

  • The T-2 detection limit in an enzyme-linked immunosorbent assay with HD11 was in the nanogram range [6].
  • The central prospective radiation oncological review of all diagnostic imaging showed that corrections of disease involvement in 49% of patients with early stages (HD10) and in 67% for patients with intermediate stages (HD11) were necessary [17].


  1. Campylobacter jejuni-induced cytokine responses in avian cells. Smith, C.K., Kaiser, P., Rothwell, L., Humphrey, T., Barrow, P.A., Jones, M.A. Infect. Immun. (2005) [Pubmed]
  2. Centralized radiation oncologic review of cross-sectional imaging of Hodgkin's disease leads to significant changes in required involved field-results of a quality assurance program of the German Hodgkin Study Group. Eich, H.T., Staar, S., Gossmann, A., Hansemann, K., Skripnitchenko, R., Kocher, M., Semrau, R., Engert, A., Josting, A., Franklin, J., Krug, B., Diehl, V., Müller, R.P. Int. J. Radiat. Oncol. Biol. Phys. (2004) [Pubmed]
  3. Structure/function studies of T-2 mycotoxin with a monoclonal antibody. Chanh, T.C., Hewetson, J.F. Immunopharmacology (1991) [Pubmed]
  4. CpG-induced immunomodulation and intracellular bacterial killing in a chicken macrophage cell line. Xie, H., Raybourne, R.B., Babu, U.S., Lillehoj, H.S., Heckert, R.A. Dev. Comp. Immunol. (2003) [Pubmed]
  5. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. Gao, L., Cueto, M.A., Asselbergs, F., Atadja, P. J. Biol. Chem. (2002) [Pubmed]
  6. Anti-idiotypic antibodies against a monoclonal antibody specific for the trichothecene mycotoxin T-2. Chanh, T.C., Huot, R.I., Schick, M.R., Hewetson, J.F. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
  7. Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene. Voelter-Mahlknecht, S., Ho, A.D., Mahlknecht, U. Int. J. Mol. Med. (2005) [Pubmed]
  8. Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours. Lindberg, D., Akerstr??m, G., Westin, G. Clin. Endocrinol. (Oxf) (2007) [Pubmed]
  9. The isolation, characterization, and molecular cloning of a 75-kDa gelatinase B-like enzyme, a member of the matrix metalloproteinase (MMP) family. An avian enzyme that is MMP-9-like in its cell expression pattern but diverges from mammalian gelatinase B in sequence and biochemical properties. Hahn-Dantona, E.A., Aimes, R.T., Quigley, J.P. J. Biol. Chem. (2000) [Pubmed]
  10. Subcellular localization and partial purification of the 25-hydroxyvitamin D3 1-hydroxylation reaction in the chick myelomonocytic cell line HD-11. Shany, S., Ren, S.Y., Arbelle, J.E., Clemens, T.L., Adams, J.S. J. Bone Miner. Res. (1993) [Pubmed]
  11. Autoregulation of 1,25-dihydroxyvitamin D synthesis in macrophage mitochondria by nitric oxide. Adams, J.S., Ren, S.Y. Endocrinology (1996) [Pubmed]
  12. Effect of TNF-alpha on LH and IGF-I modulated chicken granulosa cell proliferation and progesterone production during follicular development. Onagbesan, O.M., Mast, J., Goddeeris, B., Decuypere, E. J. Reprod. Fertil. (2000) [Pubmed]
  13. A chicken homolog of mammalian interleukin-1 beta: cDNA cloning and purification of active recombinant protein. Weining, K.C., Sick, C., Kaspers, B., Staeheli, P. Eur. J. Biochem. (1998) [Pubmed]
  14. Identification, mapping, and phylogenetic analysis of three novel chicken CC chemokines. Hughes, S., Haynes, A., O'Regan, M., Bumstead, N. Immunogenetics (2001) [Pubmed]
  15. Transformation in the use of radiation therapy of Hodgkin lymphoma: new concepts and indications lead to modern field design and are assisted by PET imaging and intensity modulated radiation therapy (IMRT). Yahalom, J. European journal of haematology. Supplementum. (2005) [Pubmed]
  16. ALK-negative anaplastic large cell lymphoma and Hodgkin's disease of nodular sclerosing type in 2 siblings. Moccia, F., Tognoni, E., Boccaccio, P. Acta Haematol. (2000) [Pubmed]
  17. The radiotherapy reference panel--experiences and results of the German Hodgkin Study Group (GHSG). Eich, H.T., Müller, R.P. European journal of haematology. Supplementum. (2005) [Pubmed]
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