Disease relevance of HPN

• A major 11-locus haplotype is significantly associated, which provides further support that HPN is a potentially important candidate gene involved in prostate cancer susceptibility [1].
• We identified overexpression of the serine protease hepsin gene in ovarian carcinomas and investigated the expression of this gene in 44 ovarian tumors (12 low malignant potential tumors and 32 carcinomas) and 10 normal ovaries [2].
• Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin [3].

High impact information on HPN

• Nickel storage is accomplished via the HPN protein, a histidine-rich protein similar to metallothionein [4].
• We have studied the association of 11 single nucleotide polymorphisms (SNPs) in the HEPSIN gene (HPN) with prostate cancer in men of European ancestry [1].
• The American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Standards for Specialized Nutrition Support: Home Care Patients, Safe Practices for Parenteral Nutrition, and Guidelines for the Use of Parenteral and Enteral Nutrition in Adult and Pediatric Patients do not contain specific information on the initiation of home PN (HPN) [5].
• The substrate specificity of TMPRSS6 is slightly different from those of other TMPRSS family members [6].

Biological context of HPN

• Association of one of the SNPs with Gleason score is also suggestive of a plausible role of HPN in tumor aggressiveness [1].

Analytical, diagnostic and therapeutic context of HPN

• Refeeding syndrome can be avoided by rehydration with fluid and electrolytes before initiation of HPN to normalize blood chemistry when necessary and by starting with a moderate-volume, low-carbohydrate HPN solution compounded with optimal potassium, phosphorus, and magnesium content, and slowly advanced to goal [5].

References