High impact information on ninaD

• However, the arrestin gene does not appear to be the ninaD locus, as sequence analysis of three ethylmethane sulfate-induced ninaD mutant alleles reveals no alteration in amino acid sequence [1].
• Drosophila ninaB and ninaD act outside of retina to produce rhodopsin chromophore [2].
• The ninaD gene encodes a membrane receptor required for efficient use of beta-carotene [2].
• In the ninaD mutant, zeaxanthin content was shown to be specifically and significantly altered compared to wild type, and was ineffective at mediating visual pigment synthesis when provided to both larval and adult mutant flies [3].
• In the present study, the larvae or adults of Drosophila melanogaster were administered specific carotenoid-containing diets and high performance liquid chromatography was used to identify and quantify the carotenoids in extracts of wild type and ninaD visual mutant flies [3].

Biological context of ninaD

• In contrast, neuron-specific expression of ninaB and ninaD allows for rhodopsin biogenesis [2].

Anatomical context of ninaD

• Moreover, a detailed noise analysis shows that photoreceptor responses of both a ninaE mutant and a ninaD mutant follow the adapting bump model [4].

Analytical, diagnostic and therapeutic context of ninaD

• Therefore, we established a Drosophila S2 cell culture system for biochemically characterizing the ninaD gene products [5].
• Identification and distribution of dietary precursors of the Drosophila visual pigment chromophore: analysis of carotenoids in wild type and ninaD mutants by HPLC [3].

References