Disease relevance of MT1DP

• MTM1, the archetypal member of this family, is mutated in X-linked myotubular myopathy, whereas mutations in the MTM-related (MTMR)2 gene cause the type 4B1 Charcot-Marie-Tooth disease, a severe hereditary motor and sensory neuropathy [1].
• If the recommended procedures are followed, the risk of acquiring HIV from saliva during MTM should be extremely low [2].

High impact information on MT1DP

• The interacting protein was shown by mass spectrometry to be MTMR5, a catalytically inactive member of the MTM family [1].
• Recent studies revealed that MTM dephosphorylates specifically phosphatidylinositol 3-phosphate [3].
• Eight MTM-related genes were found in the human genome and we determined the chromosomal localization and expression pattern for most of them [4].
• We have studied the inheritance of several polymorphic Xq27/28 DNA marker loci in two three generation families with the X linked neonatal lethal form of centronuclear/myotubular myopathy (XL MTM) [5].
• After cooling for 20 minutes and undergoing a buffer rinse, the slides were placed in a Dako autostainer (Dako-USA, Carpinteria, California, U.S.A.). The P16INK4A primary antibody, clone E6H4 (MTM Laboratories, Heidelberg, Germany) was diluted 1:200 in antibody diluent buffer [6].

Biological context of MT1DP

• Patterns of electromyographic shoulder muscle fatigue during MTM-paced repetitive arm work with and without pauses [7].

Associations of MT1DP with chemical compounds

• Myotubularins (MTM) are a large subfamily of lipid phosphatases that specifically dephosphorylate at the D3 position of phosphatidylinositol 3-phosphate (PI(3)P) in PI(3)P and PI(3,5)P(2) [8].
• Whereas a few bands might be unique to one method of isolation, most bands are the same in hexylene glycol MA and MTM MA [9].
• MA were isolated using two different stabilization media, hexylene glycol and glycerol-dimethylsulphoxide ( MTM ), because previous studies have shown that MA isolated with these solutions have different properties [9].
• The usual measured transmission method using caesium-137 single-photon sources was used without (MTM) and with segmentation of the TX data (STM) [10].

Analytical, diagnostic and therapeutic context of MT1DP

• MTM emergency lung ventilator [11].
• For health care and public safety professionals training and performance of MTM ventilation during CPR should be carried out with barrier devices such as the bag-valve-mask or face shield [2].

References