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Chemical Compound Review

Hexylene     hex-1-ene

Synonyms: Butylethylene, n-Hexene, Hexene-1, Dialene 6, Butyl ethylene, ...
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Disease relevance of Hexene


High impact information on Hexene

  • Microtubules were stabilized by hexylene glycol and inhibition of the catastrophe factor mitotic centromere-associated kinesin (MCAK) (a kinesin 13, previously called XKCM) and destabilized by depolymerizing drugs [3].
  • The appearance of chromosomes isolated by the Wray-Stubblefield hexylene glycol procedure agrees in general with previous findings of others, except that in some more extended spreads axial fibres are visible [4].
  • We studied sea-urchin zygote mitotic apparatus (MA) isolated in hexylene glycol, transferred immediately to a glycerol-dimethylsulphoxide medium, and stored for 2 weeks at room temperature [5].
  • An increase in the amount of cytoplasmic filamentous structures (cytoplasmic matrix and aster) which were recovered after hexylene glycol/Triton X-100 treatment of sea urchin eggs (Paracentrotus lividus) activated by 0.2-2.5 mM procaine was observed [6].
  • The kinetics of propene and hexene polymerisation with [(SBI)ZrR]+X-: evidence for monomer-dependent early or late transition states [7].

Biological context of Hexene

  • The potent skin sensitizers hex-1-ene- and hexane-1,3-sultone have been synthesized isotopically labeled with (13)C at reactive sites [8].
  • Inhibition of the shedding process with deuterium oxide and hexylene glycol, reduced the oxygen consumption rates of low temperature treated cells to the level of control cells [9].

Anatomical context of Hexene


Associations of Hexene with other chemical compounds

  • The two enzymes each lost activity in propylene glycol but not in a mixture of 90% hexylene glycol and 10% propylene glycol, so the glycol mixture was used as a centrifugation medium when studying enzymes [14].
  • The mitotic sea urchin egg was treated with microtubule depolymerizing (colcemid and nocodazole) and stabilizing (hexylene glycol) drugs and change in the heterogeneous distribution of the tubulin isotypes was investigated by the immunofluorescence procedure using these three monoclonal anti-tubulin antibodies [15].
  • Stopped-flow techniques of rapid mixing have been combined with energy dispersive X-ray absorption spectroscopy to monitor the reaction of Ni(dpm)2 [dpm = Bu1C(O)CHC(O)Bu1] by aluminium alkyls (AlEt2X, X = OEt and Et) to form the active species for the catalytic di- and tri-merisation of hex-1-ene [16].

Gene context of Hexene

  • MA were isolated using two different stabilization media, hexylene glycol and glycerol-dimethylsulphoxide ( MTM ), because previous studies have shown that MA isolated with these solutions have different properties [17].

Analytical, diagnostic and therapeutic context of Hexene

  • As part of our work on the characterization of these core structures, we have developed a novel procedure for the isolation of metaphase chromosomes which avoids the use of high pH buffers and hexylene glycol, as well as eliminating the numerous centrifugation and resuspension steps previously employed [18].
  • If hexylene glycol is removed, alpha-tubulin staining disappears from the polar lobe constriction, which relaxes, whereas microtubules remain in the cleavage furrow, which remains constricted [19].


  1. Toluene monooxygenase-catalyzed epoxidation of alkenes. McClay, K., Fox, B.G., Steffan, R.J. Appl. Environ. Microbiol. (2000) [Pubmed]
  2. Antibacterial and antifungal properties of propylene glycol, hexylene glycol, and 1,3-butylene glycol in vitro. Kinnunen, T., Koskela, M. Acta Derm. Venereol. (1991) [Pubmed]
  3. Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. Mitchison, T.J., Maddox, P., Gaetz, J., Groen, A., Shirasu, M., Desai, A., Salmon, E.D., Kapoor, T.M. Mol. Biol. Cell (2005) [Pubmed]
  4. Packing DNA into chromosomes. Mullinger, A.M., Johnson, R.T. J. Cell. Sci. (1980) [Pubmed]
  5. Spindle birefringence of isolated mitotic apparatus: further evidence for two birefringent spindle components. Forer, A., Kalnins, V.I., Zimmerman, A.M. J. Cell. Sci. (1976) [Pubmed]
  6. Dual effect of procaine in sea urchin eggs. Inducer and inhibitor of microtubule assembly. Coffe, G., Foucault, G., Raymond, M.N., Pudles, J. Exp. Cell Res. (1985) [Pubmed]
  7. The kinetics of propene and hexene polymerisation with [(SBI)ZrR]+X-: evidence for monomer-dependent early or late transition states. Song, F., Cannon, R.D., Bochmann, M. Chem. Commun. (Camb.) (2004) [Pubmed]
  8. Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 1. Synthesis and studies on the reactivity toward model nucleophiles of the (13)C-labeled skin sensitizers hex-1-ene- and hexane-1,3-sultones. Meschkat, E., Barratt, M.D., Lepoittevin, J. Chem. Res. Toxicol. (2001) [Pubmed]
  9. Oxygen consumption by tumor cells during membrane vesicle shedding. Liepins, A., Jayasinghe, D. Cell Biol. Int. Rep. (1985) [Pubmed]
  10. Microtubule plus-end dynamics in Xenopus egg extract spindles. Tirnauer, J.S., Salmon, E.D., Mitchison, T.J. Mol. Biol. Cell (2004) [Pubmed]
  11. The avian erythrocyte: a study of fixation for electron microscopy. Brown, J.N. Journal of microscopy. (1975) [Pubmed]
  12. Cytoskeleton of the unfertilized sea urchin egg. Foucault, G., Raymond, M.N., Pudles, J. Biol. Cell (1987) [Pubmed]
  13. Experimental determinations of tubulin in the in vivo mitotic apparatus of sea urchin zygotes. Forer, A., Larson, D.E., Zimmerman, A.M. Can. J. Biochem. (1980) [Pubmed]
  14. Nonaqueous fractionation of HeLa cells in glycols. Gurney, T., Collard, M.W. Anal. Biochem. (1984) [Pubmed]
  15. Change in the heterogeneous distribution of tubulin isotypes in mitotic microtubules of the sea urchin egg by treatment with microtubule depolymerizing or stabilizing drugs. Oka, M.T., Arai, T., Hamaguchi, Y. Cell Struct. Funct. (1991) [Pubmed]
  16. Application of stopped flow techniques and energy dispersive EXAFS for investigation of the reactions of transition metal complexes in solution: activation of nickel beta-diketonates to form homogeneous catalysts, electron transfer reactions involving iron(III) and oxidative addition to iridium(I). Abdul Rahman, M.B., Bolton, P.R., Evans, J., Dent, A.J., Harvey, I., Diaz-Moreno, S. Faraday Discuss. (2003) [Pubmed]
  17. Composition of the isolated mitotic apparatus: analysis by polyacrylamide gel electrophoresis. Forer, A., Zimmerman, A.M. Cytobios (1984) [Pubmed]
  18. Chinese hamster metaphase chromosomes isolated under physiological conditions. A partial characterization of associated non-histone proteins and protein cores. Gooderham, K., Jeppesen, P. Exp. Cell Res. (1983) [Pubmed]
  19. Effect of hexylene glycol-altered microtubule distributions on cytokinesis and polar lobe formation in fertilized eggs of Ilyanassa obsoleta. Conrad, A.H., Stephens, A.P., Conrad, G.W. J. Exp. Zool. (1994) [Pubmed]
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