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Gene Review

ERAS  -  ES cell expressed Ras

Homo sapiens

Synonyms: E-Ras, Embryonic stem cell-expressed Ras, GTPase ERas, HRAS2, HRASP
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Disease relevance of ERAS


High impact information on ERAS

  • Polymerase chain reaction-single-strand conformation polymorphism analysis and DNA sequencing of the induced lung tumors revealed point mutations at codon 61 of the transgene in two of 29 lung tumors (one of 16 in males and one of 13 in females) from VC-treated Hras2 mice; no mutations in murine Ki-ras were found in these tumors [1].
  • Choosing a future for epidemiology: I. Eras and paradigms [3].
  • Diminished Sexual Activity, Interest, and Feelings of Attractiveness Among HIV-Infected Women in Two Eras of the AIDS Epidemic [4].
  • Since the human HRAS-2 also resides on the X chromosome, it appears that the cellular HRAS-2 gene (or pseudogene) conserved its chromosomal localization during mammalian evolution [5].

Analytical, diagnostic and therapeutic context of ERAS

  • Throughout all four Eras, a selective operative approach, using the distal splenorenal shunt (DSRS), nonselective shunts, and esophagogastric devascularization, was taken [6].
  • Four Eras separated by the dates when endoscopic therapy (January 1981), liver transplantation (July 1985), and TIPS (January 1993) became available in our institution were analyzed [6].


  1. Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors. Mitsumori, K., Wakana, S., Yamamoto, S., Kodama, Y., Yasuhara, K., Nomura, T., Hayashi, Y., Maronpot, R.R. Mol. Carcinog. (1997) [Pubmed]
  2. Changes in attitudes toward antiviral medication: a comparison of women living with HIV/AIDS in the pre-HAART and HAART Eras. Schrimshaw, E.W., Siegel, K., Lekas, H.M. AIDS and behavior. (2005) [Pubmed]
  3. Choosing a future for epidemiology: I. Eras and paradigms. Susser, M., Susser, E. American journal of public health. (1996) [Pubmed]
  4. Diminished Sexual Activity, Interest, and Feelings of Attractiveness Among HIV-Infected Women in Two Eras of the AIDS Epidemic. Siegel, K., Schrimshaw, E.W., Lekas, H.M. Archives of sexual behavior. (2006) [Pubmed]
  5. Assignment of three rat cellular RAS oncogenes to chromosomes 1, 4, and X. Szpirer, J., Defeo-Jones, D., Ellis, R.W., Levan, G., Szpirer, C. Somat. Cell Mol. Genet. (1985) [Pubmed]
  6. The changing spectrum of treatment for variceal bleeding. Rikkers, L.F. Ann. Surg. (1998) [Pubmed]
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