Disease relevance of Splenorenal Shunt, Surgical

• The Linton splenorenal shunt in the management of the bleeding complications of portal hypertension [1].
• Twelve patients with alcoholic cirrhosis with distal splenorenal shunt received propranolol in a dose sufficient to provide beta blockade [2].
• Losartan at 10 mg/kg per day significantly worsened liver and renal functions, mortality and liver fibrosis, without significant changes in portal pressure and splenorenal shunt blood flow [3].
• Ten patients with both hepatocellular carcinoma (HCC) and esophageal or esophagogastric varices were concurrently treated by partial hepatic resection and distal splenorenal shunt [4].
• Recurrent hypersplenism caused by alcoholic cardiomyopathy after distal splenorenal shunt [5].

High impact information on Splenorenal Shunt, Surgical

• Throughout all four Eras, a selective operative approach, using the distal splenorenal shunt (DSRS), nonselective shunts, and esophagogastric devascularization, was taken [6].
• This report describes 140 cases in which Linton splenorenal shunts were performed for the management of the complications of portal hypertension by a large number of surgeons in a single hospital [1].
• In five cirrhotic patients fasting and postprandial gastrin levels were unchanged after splenorenal shunt operation [7].
• Images in hepatology. Large splenorenal shunt in portal venous obstruction [8].
• Portal vein pressure was elevated in one patient with idiopathic portal hypertension in whom portal venous flow was increased postoperatively as a result of resection of a large gastro- and splenorenal shunt conducted additionally [9].

Chemical compound and disease context of Splenorenal Shunt, Surgical

• Use of balloon-occluded retrograde transvenous obliteration with ethanolamine oleate for the treatment of hepatic encephalopathy in a cirrhotic patient with a large spontaneous splenorenal shunt [10].
• In this study, we carried out percutaneous transhepatic portography and investigated pancreatic hormone kinetics in portal blood after arginine load, mainly in cases of hepatic encephalopathy after distal splenorenal shunt compared with non-encephalopathy cases of LC + Varix [11].

Anatomical context of Splenorenal Shunt, Surgical

• Natural splenorenal shunts were visible in 19 children but were not clearly associated with a lower risk of gastrointestinal tract bleeding; in five of 30 children, cavography displayed abnormalities of the inferior vena cava [12].
• Other major venous abnormalities included duplications of inferior vena cava and retroaortic left renal vein and spontaneous splenorenal shunt which were all correctly diagnosed preoperatively [13].

Associations of Splenorenal Shunt, Surgical with chemical compounds

• Eighty-eight patients received a shunt: 54, a narrow-lumen mesocaval (NLMS) shunt; 32, a distal splenorenal shunt; 1, a portacaval shunt; and 1, a proximal splenorenal Linton shunt [14].
• Although preoperative hepatic functional reserve is the major determinant of postoperative bilirubin concentration, alterations in hepatic hemodynamics secondary to the distal splenorenal shunt may also play a role [15].
• Octreotide significantly decreased splenorenal shunt blood flow: -23 +/- 20% (P < 0.01) vs -6 +/- 8% (not significant) in placebo rats [16].
• The variation of splenorenal shunt blood flow after vapreotide was significant but not that of the splenic percentage of portosystemic shunts compared to placebo [16].
• Effect of distal splenorenal shunt plus splenopancreatic disconnection on glucose and amino acid metabolism [17].

Gene context of Splenorenal Shunt, Surgical

• Results of celiac arteriograms and direct examination confirmed the patency of the distal splenorenal shunt [18].
• Two patients with alpha-1-antitrypsin deficiency (PiZZ) and associated portal hypertension, cirrhosis, and hypersplenism underwent splenorenal shunt and splenectomy 8 yr ago, and both have done well [19].
• BACKGROUND/AIMS: Distal splenorenal shunt with splenopancreatic disconnection (DSRS + SPD) evolved to prevent the development of a pancreatic siphon, to improve maintenance as well as quality of portal perfusion and to achieve better long-term survival [20].
• These data suggested that as a cause of encephalopathy after distal splenorenal shunt, (1) a marked decrease in portal blood flow due to portal systemic shunt via the pancreatic vein was considered from PTP image, (2) a marked decrease in I/G ratio was considered from pancreatic hormone kinetics in portal blood [11].

Analytical, diagnostic and therapeutic context of Splenorenal Shunt, Surgical

• This study tested the hypothesis that reduction in the hyperdynamic systemic circulation with propranolol in patients with alcoholic cirrhosis and distal splenorenal shunt would lead to improved maintenance of portal perfusion [2].
• This technique, along with selective celiac arterial, superior mesenteric arterial, and renal venous catheterization, was used in the evaluation of a series of 17 splenorenal venous shunts [eight nonselective and nine selective (modified) distal splenorenal shunts] [21].
• These included blood flow in the left gastric (coronary) vein toward the liver due to occluded or stenotic splenorenal shunts, spontaneous left gastric vein to inferior vena cava shunts, and failure of powdered Gelfoam and heat-treated autogenous clot to cause permanent occlusion [22].
• We report herein the case of a 60-year-old man who developed hepatic failure with simultaneous transient hepatofugal portal blood flow after undergoing hepatectomy for hepatocellular carcinoma accompanied by cirrhosis with a splenorenal shunt [23].

References