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Gene Review

Vav  -  Vav ortholog (H. sapiens)

Drosophila melanogaster

Synonyms: BcDNA:GH01128, CG7893, Dmel\CG7893, DroVav, Protein vav, ...
 
 
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Psychiatry related information on vav

  • Indeed, the EZH2 protein has been shown to associate with the Vav proto-oncoprotein and with the XNP protein, the product of a mental retardation gene [1].
 

High impact information on vav

  • Furthermore, vav overexpression enhances basal and T-cell receptor (TCR)-mediated stimulation of the nuclear factor of activated T cells (NFAT) [2].
  • hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways [2].
  • Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression [3].
  • Dominant-negative DRac abrogated these morphological changes, suggesting that the effect of the truncated DroVav mutant is mediated by activation of DRac [4].
  • In Drosophila cells, we find that stimulation of the Drosophila EGF receptor (DER) increases tyrosine phosphorylation of DroVav, which in turn associates with tyrosine-phosphorylated DER [4].
 

Biological context of vav

  • DroVav is located on the X chromosome in polytene interval 18A5;18B and is expressed in all stages of development and in all tissues [5].
  • As a consequence, Drosophila Vav can trigger oncogenic transformation, morphological change, and enhanced cell motility in mammalian cells [6].
 

Analytical, diagnostic and therapeutic context of vav

  • Thus, DroVav probably plays a pivotal role as a signal transducer protein during fruit fly development [5].

References

  1. The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders. Cardoso, C., Mignon, C., Hetet, G., Grandchamps, B., Fontes, M., Colleaux, L. Eur. J. Hum. Genet. (2000) [Pubmed]
  2. hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. Germani, A., Romero, F., Houlard, M., Camonis, J., Gisselbrecht, S., Fischer, S., Varin-Blank, N. Mol. Cell. Biol. (1999) [Pubmed]
  3. Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Hobert, O., Jallal, B., Ullrich, A. Mol. Cell. Biol. (1996) [Pubmed]
  4. DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways. Hornstein, I., Mortin, M.A., Katzav, S. Oncogene (2003) [Pubmed]
  5. Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav. Dekel, I., Russek, N., Jones, T., Mortin, M.A., Katzav, S. FEBS Lett. (2000) [Pubmed]
  6. Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family. Couceiro, J.R., Martín-Bermudo, M.D., Bustelo, X.R. Exp. Cell Res. (2005) [Pubmed]
 
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