Gene Review:
SIAH2 - siah E3 ubiquitin protein ligase 2
Homo sapiens
Synonyms:
E3 ubiquitin-protein ligase SIAH2, Seven in absentia homolog 2, Siah-2, hSiah2
- Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Hu, G., Fearon, E.R. Mol. Cell. Biol. (1999)
- Regulation of the Ring Finger E3 Ligase Siah2 by p38 MAPK. Khurana, A., Nakayama, K., Williams, S., Davis, R.J., Mustelin, T., Ronai, Z. J. Biol. Chem. (2006)
- Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia. Simon, M.C. Cell (2004)
- Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Nakayama, K., Frew, I.J., Hagensen, M., Skals, M., Habelhah, H., Bhoumik, A., Kadoya, T., Erdjument-Bromage, H., Tempst, P., Frappell, P.B., Bowtell, D.D., Ronai, Z. Cell (2004)
- Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation. Gutierrez, G.J., V??gtlin, A., Castro, A., Ferby, I., Salvagiotto, G., Ronai, Z., Lorca, T., Nebreda, A.R. Nat. Cell Biol. (2006)
- Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes. Frasor, J., Danes, J.M., Funk, C.C., Katzenellenbogen, B.S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Characterization of human homologs of the Drosophila seven in absentia (sina) gene. Hu, G., Chung, Y.L., Glover, T., Valentine, V., Look, A.T., Fearon, E.R. Genomics (1997)
- A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q. Joensuu, T., Hämäläinen, R., Lehesjoki, A.E., de la Chapelle, A., Sankila, E.M. Genomics (2000)
- Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2. Nadeau, R.J., Toher, J.L., Yang, X., Kovalenko, D., Friesel, R. J. Cell. Biochem. (2007)
- The RING domain of Siaz, the zebrafish homologue of Drosophila seven in absentia, is essential for cellular growth arrest. Ro, H., Jang, Y., Rhee, M. Mol. Cells (2004)
- hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. Germani, A., Romero, F., Houlard, M., Camonis, J., Gisselbrecht, S., Fischer, S., Varin-Blank, N. Mol. Cell. Biol. (1999)
- Regulation of BOB.1/OBF.1 stability by SIAH. Boehm, J., He, Y., Greiner, A., Staudt, L., Wirth, T. EMBO J. (2001)
- Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease. Liani, E., Eyal, A., Avraham, E., Shemer, R., Szargel, R., Berg, D., Bornemann, A., Riess, O., Ross, C.A., Rott, R., Engelender, S. Proc. Natl. Acad. Sci. U.S.A. (2004)