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Gene Review:

SNAI3 - snail family zinc finger 3

Homo sapiens

Synonyms: Protein snail homolog 3, SMUC, SNAIL3, ZNF293, Zfp293, ...

Katoh, M. et al., Katoh, M. et al.

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Disease relevance of SNAI3

Human SNAI3 mRNA was expressed in skin melanotic melanoma, lung epidermoid carcinoma, and germ cell tumor [1].

High impact information on SNAI3

Based on the integromics analyses, SNAI2 orthologs were found to be more conserved than SNAI1 and SNAI3 orthologs [2].
SNAI3 mRNA was expressed in B cells [2].
Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs [2].
These results clearly indicate that SNAI1, SNAI2 and SNAI3 constitute a subfamily among SNAG zinc-finger proteins [1].
Human SNAI3 gene, consisting of at least three exons, spans around the nucleotide position 320214-328221 of human reference genomic contig NT_010404.8 in the reverse orientation [1].

Biological context of SNAI3

Human SNAI3 gene was found to encode 292-amino-acid polypeptide with the N-terminal SNAG domain and five zinc finger domains [1].
Because SNAG zinc-finger proteins are transcriptional repressors implicated in carcinogenesis and embryogenesis, SNAI3 gene might be a potent target of pharmacogenomics in the field of oncology and regenerative medicine [1].
Here, we have identified human SNAIL3 (SNAI3) gene using bioinformatics [1].

References

Identification and characterization of human SNAIL3 (SNAI3) gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs. Katoh, M., Katoh, M. Oncol. Rep. (2005) [Pubmed]

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