Gene Review:
SNAI2 - snail family zinc finger 2
Homo sapiens
Synonyms:
Neural crest transcription factor Slug, Protein snail homolog 2, SLUG, SLUGH, SLUGH1, ...
- Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs. Katoh, M., Katoh, M. Oncol. Rep. (2005)
- Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E-cadherin. Alves, C.C., Rosivatz, E., Schott, C., Hollweck, R., Becker, I., Sarbia, M., Carneiro, F., Becker, K.F. J. Pathol. (2007)
- Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region. Stegmann, K., Boecker, J., Kosan, C., Ermert, A., Kunz, J., Koch, M.C. Mutat. Res. (1999)
- SLUG in cancer development. Pérez-Mancera, P.A., González-Herrero, I., Pérez-Caro, M., Gutiérrez-Cianca, N., Flores, T., Gutiérrez-Adán, A., Pintado, B., Sánchez-Martín, M., Sánchez-García, I. Oncogene (2005)
- SLUG (SNAI2) overexpression in embryonic development. Pérez-Mancera, P.A., González-Herrero, I., Maclean, K., Turner, A.M., Yip, M.Y., Sánchez-Martín, M., García, J.L., Robledo, C., Flores, T., Gutiérrez-Adán, A., Pintado, B., Sánchez-García, I. Cytogenet. Genome Res. (2006)
- Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Nieto, M.A., Sargent, M.G., Wilkinson, D.G., Cooke, J. Science (1994)
- Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Giannelli, G., Bergamini, C., Fransvea, E., Sgarra, C., Antonaci, S. Gastroenterology (2005)
- Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. Conacci-Sorrell, M., Simcha, I., Ben-Yedidia, T., Blechman, J., Savagner, P., Ben-Ze'ev, A. J. Cell Biol. (2003)
- Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Kajita, M., McClinic, K.N., Wade, P.A. Mol. Cell. Biol. (2004)
- Identification and characterization of human SNAIL3 (SNAI3) gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003)
- Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. Catalano, A., Rodilossi, S., Rippo, M.R., Caprari, P., Procopio, A. J. Biol. Chem. (2004)
- Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. Turner, F.E., Broad, S., Khanim, F.L., Jeanes, A., Talma, S., Hughes, S., Tselepis, C., Hotchin, N.A. J. Biol. Chem. (2006)
- Snail and slug play distinct roles during breast carcinoma progression. C??me, C., Magnino, F., Bibeau, F., De Santa Barbara, P., Becker, K.F., Theillet, C., Savagner, P. Clin. Cancer Res. (2006)
- Slug (SNAI2) down-regulation by RNA interference facilitates apoptosis and inhibits invasive growth in neuroblastoma preclinical models. Vitali, R., Mancini, C., Cesi, V., Tanno, B., Mancuso, M., Bossi, G., Zhang, Y., Martinez, R.V., Calabretta, B., Dominici, C., Raschellà, G. Clin. Cancer Res. (2008)
- Human SLUG does not directly bind to CtBP1. Bailey, C.K., Misra, S., Mittal, M.K., Chaudhuri, G. Biochem. Biophys. Res. Commun. (2007)
- The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells. Martínez-Estrada, O.M., Cullerés, A., Soriano, F.X., Peinado, H., Bolós, V., Martínez, F.O., Reina, M., Cano, A., Fabre, M., Vilaró, S. Biochem. J. (2006)
- Epithelial cell plasticity in development and tumor progression. Thiery, J.P., Chopin, D. Cancer Metastasis Rev. (1999)
- Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma. Uchikado, Y., Natsugoe, S., Okumura, H., Setoyama, T., Matsumoto, M., Ishigami, S., Aikou, T. Clin. Cancer Res. (2005)
- Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Yang, A.D., Camp, E.R., Fan, F., Shen, L., Gray, M.J., Liu, W., Somcio, R., Bauer, T.W., Wu, Y., Hicklin, D.J., Ellis, L.M. Cancer Res. (2006)
- Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Elloul, S., Elstrand, M.B., Nesland, J.M., Tropé, C.G., Kvalheim, G., Goldberg, I., Reich, R., Davidson, B. Cancer (2005)
- Deletion of the SLUG (SNAI2) gene results in human piebaldism. Sánchez-Martín, M., Pérez-Losada, J., Rodríguez-García, A., González-Sánchez, B., Korf, B.R., Kuster, W., Moss, C., Spritz, R.A., Sánchez-García, I. Am. J. Med. Genet. A (2003)
- Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Martin, T.A., Goyal, A., Watkins, G., Jiang, W.G. Ann. Surg. Oncol. (2005)
- Zinc finger transcription factor Slug is a novel target gene of aryl hydrocarbon receptor. Ikuta, T., Kawajiri, K. Exp. Cell Res. (2006)