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MeSH Review:

Regenerative Medicine

Katoh, M., Heng, B.C. et al., Heng, B.C. et al., Katoh, Y. et al., Katoh, Y. et al., et al.

Braddock, Campbell, Houston, Kume, Katoh,

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Disease relevance of Regenerative Medicine

WNT11 gene at human chromosome 11q13.5 encodes non-canonical WNT11 protein, which is applicable for regenerative medicine of heart diseases [1].

High impact information on Regenerative Medicine

These results suggest that the use of GSK-3-specific inhibitors such as BIO may have practical applications in regenerative medicine [2].
Stem cell-based regenerative medicine therapies have been touted recently as a novel therapeutic approach to treat and cure a wide range of diseases [3].
EPHA7 is a target of systems medicine, especially in the fields of regenerative medicine and oncology [4].
EFNB3, identified as potential transcriptional target of WNT/beta-catenin signaling pathway, is a pharmacogenomics target in the fields of regenerative medicine and oncology [5].
Because GDF10 was characterized as a potential target of canonical WNT signaling pathway in neural tissues, GDF10 is one of the targets of systems medicine, especially in the field of regenerative medicine [6].

Biological context of Regenerative Medicine

TMEM25 is a target of pharmacogenomics in the field of oncology and regenerative medicine [7].
Incorporating protein transduction domains (PTD) within intracellular proteins associated with the 'stemness' phenotype. Novel use of such recombinant 'fusion' proteins to overcome current limitations of applying autologous adult stem cells in regenerative medicine [8]?

Gene context of Regenerative Medicine

These facts indicate that FGF16, FGF18 and FGF20 are pharmacogenomics targets in the field of oncology and regenerative medicine [9].
We have cloned and characterized 13 out of 19 human WNT genes, and also 9 out of 10 human Frizzled (FZD) genes encoding seven-transmembrane-type WNT receptors, which are potent targets for pharmacogenomics in the post-genomic era, especially in the field of regenerative medicine and clinical oncology [10].
Therapeutic applications of the transcriptional corepressor proteins NAB1 and NAB2 in regenerative medicine [11].
Stem-cell-based approaches for regenerative medicine [12].
hES (human embryonic stem) cells hold tremendous potential in the newly emerging field of regenerative medicine, in addition to being a useful tool in basic scientific research and for pharmacological and cytotoxicity screening [13].

References

Comparative genomics on Wnt11 gene. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., Brivanlou, A.H. Nat. Med. (2004) [Pubmed]
Nonhuman primate embryonic stem cells as a preclinical model for hematopoietic and vascular repair. Hematti, P., Obrtlikova, P., Kaufman, D.S. Exp. Hematol. (2005) [Pubmed]
Comparative integromics on Eph family. Katoh, M., Katoh, M. Int. J. Oncol. (2006) [Pubmed]
Comparative integromics on Ephrin family. Katoh, Y., Katoh, M. Oncol. Rep. (2006) [Pubmed]
Comparative integromics on BMP/GDF family. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
Identification and characterization of human TMEM25 and mouse Tmem25 genes in silico. Katoh, M., Katoh, M. Oncol. Rep. (2004) [Pubmed]
Incorporating protein transduction domains (PTD) within intracellular proteins associated with the 'stemness' phenotype. Novel use of such recombinant 'fusion' proteins to overcome current limitations of applying autologous adult stem cells in regenerative medicine? Heng, B.C., Cao, T. Med. Hypotheses (2005) [Pubmed]
Comparative genomics on FGF16 orthologs. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review). Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
Therapeutic applications of the transcriptional corepressor proteins NAB1 and NAB2 in regenerative medicine. Braddock, M., Campbell, C.J., Houston, P. IDrugs : the investigational drugs journal. (2000) [Pubmed]
Stem-cell-based approaches for regenerative medicine. Kume, S. Dev. Growth Differ. (2005) [Pubmed]
The cryopreservation of human embryonic stem cells. Heng, B.C., Kuleshova, L.L., Bested, S.M., Liu, H., Cao, T. Biotechnol. Appl. Biochem. (2005) [Pubmed]

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